In the intricate world of organic synthesis, the availability of well-defined and high-purity chemical intermediates is paramount. Among these essential building blocks, halogenated aromatic compounds, particularly iodinated ones, hold a special place due to their versatile reactivity. One such compound that plays a crucial role in various synthetic strategies is 1,3-dimethyl-5-iodobenzene (CAS No: 22445-41-6).

Understanding the Role of 1,3-Dimethyl-5-iodobenzene in Organic Synthesis

1,3-Dimethyl-5-iodobenzene, also known by its synonym 1-Iodo-3,5-dimethylbenzene, is a key organic synthesis intermediate. Its molecular formula, C8H9I, and molecular weight of 232.061, hint at its structural significance. The presence of the iodine atom makes it an excellent substrate for a wide range of palladium-catalyzed cross-coupling reactions, such as Suzuki, Heck, and Sonogashira couplings. These reactions are fundamental for forming new carbon-carbon bonds, which is a cornerstone of constructing complex organic molecules.

The two methyl groups at the 1 and 3 positions of the benzene ring not only influence the electronic properties but also provide steric bulk, which can be advantageous in controlling regioselectivity and stereoselectivity in subsequent reactions. This makes 1,3-dimethyl-5-iodobenzene a valuable starting material for synthesizing fine chemicals, pharmaceuticals, and advanced materials where precise molecular architecture is required.

Key Properties and Sourcing Considerations

From a physical properties standpoint, 1,3-dimethyl-5-iodobenzene typically appears as a pink-brown to red transparent liquid. Its density is approximately 1.6±0.1 g/cm³, and it has a boiling point of 229.9±9.0 °C at 760 mmHg. With an index of refraction of 1.593, these physical characteristics are important for identification and quality control. A high assay of ≥98.0% is typically specified, ensuring that researchers can rely on its purity for reproducible experimental outcomes. When considering the purchase of such compounds, it is essential to partner with reputable suppliers who can guarantee consistent quality and purity.

Applications and Future Potential

The utility of 1,3-dimethyl-5-iodobenzene extends to various research and development sectors. Its ability to participate in a broad spectrum of organic transformations makes it a sought-after reagent for synthetic chemists. As the demand for novel compounds with specific functionalities grows, the importance of intermediates like 1,3-dimethyl-5-iodobenzene, which facilitate efficient synthesis, will only increase. Exploring different prices and availability from various manufacturers can help optimize procurement strategies for your laboratory's needs.

In conclusion, 1,3-dimethyl-5-iodobenzene is more than just a chemical; it is a gateway to creating complex molecular structures. Its reliable buy options from trusted sources ensure that scientific endeavors can progress without compromise. For anyone involved in advanced organic synthesis, understanding the value and application of such intermediates is key to unlocking new chemical frontiers.