The pharmaceutical industry thrives on the precise synthesis of complex molecules, often relying on versatile intermediate compounds to build the final active pharmaceutical ingredients (APIs). One such key intermediate is 4-(4-Chlorophenyl)piperidin-4-ol, identified by its CAS number 39512-49-7. This compound, known for its specific chemical structure and purity, is integral to the production of various pharmaceuticals, most notably Loperamide hydrochloride.

With a molecular formula of C11H14ClNO and a molecular weight of 211.69 g/mol, 4-(4-Chlorophenyl)piperidin-4-ol exhibits a range of properties that make it suitable for demanding synthetic applications. Typically supplied as a white to yellow crystalline powder, its physical state signifies a product that has undergone significant purification. Its melting point, generally falling between 137-140°C, points to a stable crystalline structure. The compound's density, around 1.2 g/cm³, and flash point, approximately 162.1°C, are important parameters for safe industrial handling and storage. These characteristics are crucial for manufacturers aiming to incorporate it efficiently into their synthetic pathways.

The primary and most recognized application of 4-(4-Chlorophenyl)piperidin-4-ol is as a precursor in the synthesis of Loperamide hydrochloride, a widely used medication for managing diarrhea. The chemical structure of the intermediate provides essential functional groups that are elaborated upon through several reaction steps to yield the final API. The high purity of this intermediate, often specified at ≥98.0% assay, is paramount to ensuring the quality and safety of the resultant Loperamide hydrochloride. Impurities in the intermediate could lead to unacceptable levels in the final drug product, impacting its therapeutic efficacy and compliance with regulatory standards.

As a versatile intermediate, 4-(4-Chlorophenyl)piperidin-4-ol is also of interest in broader medicinal chemistry research. Its piperidine core and functionalized phenyl ring make it a potential building block for exploring novel therapeutic agents. For pharmaceutical companies and contract research organizations, securing a consistent and high-quality supply of this compound from reliable manufacturers, such as those in China specializing in fine chemical intermediates, is a critical factor for success in drug development and production. The availability of such key intermediates fuels innovation and ensures the continuous supply of essential medicines.