Unlocking Tablet Performance: The Power of Superdisintegrants like Sodium Starch Glycolate at NINGBO INNO PHARMCHEM CO.,LTD.
At NINGBO INNO PHARMCHEM CO.,LTD., our mission is to craft pharmaceutical products that are both effective and reliable. Central to achieving this is the meticulous selection of excipients, particularly those that influence a tablet's disintegration and dissolution. Sodium Starch Glycolate (SSG) is a prime example of such an excipient, serving as a potent superdisintegrant that significantly elevates tablet performance. Our deep understanding of SSG allows us to engineer tablets with optimal physical characteristics and rapid drug release profiles.
Sodium Starch Glycolate is a chemical marvel derived from starch, specifically engineered for superior water uptake and swelling. This characteristic is fundamental to its function as a disintegrant. When a tablet formulated with SSG is exposed to moisture, the SSG particles rapidly hydrate, expand, and generate an internal force. This force systematically disrupts the bonds holding the tablet matrix together, causing it to break apart swiftly into smaller particles. This process is critical for ensuring that the active pharmaceutical ingredient (API) is readily available for dissolution and subsequent absorption in the body. We consider this rapid expansion in cold water a key attribute that benefits a wide array of therapeutic applications.
The dual action of SSG in enhancing both tablet hardness and disintegration efficiency is particularly valuable. For pharmaceutical manufacturers, achieving a balance between tablet integrity – ensuring it withstands handling and transport – and rapid disintegration upon administration can be challenging. SSG provides a solution by reinforcing the tablet structure while simultaneously facilitating its breakdown. This makes it an excellent choice for formulations requiring improved physical robustness without compromising on drug release kinetics. Our formulation scientists at NINGBO INNO PHARMCHEM CO.,LTD. expertly balance the dosage, typically between 2% to 10%, to achieve these desired outcomes.
Moreover, the cost-effectiveness and broad applicability of SSG make it a cornerstone in our formulation strategies. Whether employing direct compression or wet granulation, SSG integrates seamlessly into the manufacturing process. Its ability to improve the bioavailability of poorly soluble drugs is another significant advantage that we leverage to create more effective medications. NINGBO INNO PHARMCHEM CO.,LTD. is committed to utilizing premium-grade Sodium Starch Glycolate to ensure consistent quality and performance, thereby contributing to the development of patient-centric pharmaceutical solutions that are both efficient and reliable.
Perspectives & Insights
Chem Catalyst Pro
“Sodium Starch Glycolate is a chemical marvel derived from starch, specifically engineered for superior water uptake and swelling.”
Agile Thinker 7
“When a tablet formulated with SSG is exposed to moisture, the SSG particles rapidly hydrate, expand, and generate an internal force.”
Logic Spark 24
“This force systematically disrupts the bonds holding the tablet matrix together, causing it to break apart swiftly into smaller particles.”