Glycylglycine: The Simplest Dipeptide for Biochemical Research and Buffering Applications
Discover the versatile applications of Glycylglycine as a crucial biochemical reagent and effective buffer.
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Glycylglycine
Glycylglycine, a dipeptide formed from two glycine units, stands as the simplest peptide. First synthesized in 1901, it is recognized for its low toxicity and utility as a buffering agent in biological systems, offering effective ranges between pH 2.5-3.8 and 7.5-8.9. Its capacity to aid in the solubilization of recombinant proteins in E. coli and its role as a foundational element for creating more complex peptides underscore its importance in various scientific disciplines.
- Utilizing Glycylglycine's buffer range, researchers can maintain stable pH for sensitive biological experiments.
- The ability of glycylglycine to improve protein solubility is critical for efficient recombinant protein production.
- As a biochemical reagent, Glycylglycine is indispensable for studies focused on peptide transport and absorption mechanisms.
- Understanding the glycylglycine synthesis pathways provides insights into peptide bond formation critical for biochemistry.
Product Advantages
Simplicity and Purity
As the simplest peptide, Glycylglycine offers a clean starting point for research, facilitating a clearer understanding of peptide behavior and interactions, essential when exploring specific biochemical reagent applications.
Effective Buffering
With a reliable glycylglycine buffer range, it provides stable pH control in biological assays, proving highly valuable for experiments investigating peptide transport and absorption.
Protein Solubility Enhancement
Glycylglycine's proven ability to enhance recombinant protein solubility is a significant advantage, simplifying protein purification processes and improving yields for researchers.
Key Applications
Biochemical Research
Glycylglycine is a cornerstone biochemical reagent, utilized in studies exploring enzyme kinetics, protein-ligand interactions, and cellular transport mechanisms.
Buffer Agent
Its well-defined glycylglycine buffer range makes it ideal for maintaining physiological pH in cell culture media and various biochemical assays.
Protein Solubilization
The use of glycylglycine in improving protein solubility is a key application in biotechnology, aiding the expression and purification of challenging proteins.
Peptide Synthesis
As a fundamental dipeptide, Glycylglycine serves as a crucial building block in the synthesis of longer, more complex peptides for therapeutic and research purposes.