In the sphere of advanced chemical synthesis, specialized intermediates are the backbone of innovation, enabling the creation of sophisticated end products. 3-Chloro-4-fluorotoluene, identified by its CAS number 1513-25-3, is one such vital intermediate, playing a critical role in the pharmaceutical and agrochemical industries. This article explores its key attributes and applications, emphasizing its value as a sourcing option from China.

Understanding the Chemistry of 3-Chloro-4-fluorotoluene

The compound 3-Chloro-4-fluorotoluene, with molecular formula C7H6ClF and molecular weight 144.57400, is recognized as a colorless to light yellow transparent liquid. Its physical properties are notable: a boiling point of 167°C and a flash point of 45.4°C define it as a flammable liquid, requiring careful handling and storage. The density is 1.358 g/cm³. The distinctive feature of this molecule is the presence of both chlorine and fluorine atoms on the aromatic ring, which provide unique reactivity and make it highly adaptable for various synthetic pathways. This makes it an attractive intermediate for creating complex organic molecules with specific desired properties.

Applications in Pharmaceutical Development

Within the pharmaceutical sector, 3-Chloro-4-fluorotoluene is a cornerstone for synthesizing Active Pharmaceutical Ingredients (APIs). Its chemical structure serves as a valuable scaffold for medicinal chemists, allowing for the introduction of specific functionalities that influence a drug's efficacy, safety profile, and metabolic behavior. As a key component in pharmaceutical intermediates, its consistent quality and high purity (≥98%) are critical. Manufacturers in China are increasingly recognized for their capability to supply this compound reliably, supporting the global drug development pipeline and ensuring the production of high-quality medicines.

Significance in Agrochemical Production

The agrochemical industry also benefits greatly from the versatility of 3-Chloro-4-fluorotoluene. It is employed as a precursor in the synthesis of a wide array of crop protection products, including herbicides, pesticides, and fungicides. These agents are fundamental to modern agriculture, helping to secure food supplies by protecting crops from pests and diseases. The ability to fine-tune the chemical structure through intermediates like 3-Chloro-4-fluorotoluene allows for the development of more potent and selective agrochemicals. Sourcing from reliable agrochemical intermediate manufacturers in China ensures the quality and availability needed for large-scale agricultural applications.

Procurement and Safe Handling

For businesses seeking to leverage the benefits of 3-Chloro-4-fluorotoluene, reliable sourcing is key. It is typically supplied in 25kg drums, suitable for industrial quantities. Given its classification as a flammable liquid, it must be stored in cool, dry, and well-ventilated areas, away from heat and ignition sources. Adherence to safety data sheets and best practices ensures the compound’s integrity and safe use throughout the production process.

In summary, 3-Chloro-4-fluorotoluene (CAS 1513-25-3) is a pivotal intermediate that drives innovation in both the pharmaceutical and agrochemical industries. Its unique chemical properties and its availability from manufacturers in China make it an essential component for creating advanced chemical products.