Organic synthesis is the cornerstone of much of modern chemistry, enabling the creation of new molecules for a vast array of applications. For laboratory researchers, having access to versatile and reliable building blocks is essential. 1-Bromo-4-fluorobutane (CAS: 462-72-6) is a prime example of such a compound, offering unique reactivity that makes it a valuable tool in the synthetic chemist's arsenal.

Understanding the Reactivity of 1-Bromo-4-fluorobutane

The key to 1-Bromo-4-fluorobutane's utility lies in its bifunctional nature. The presence of both a bromine atom and a fluorine atom on the same molecule allows for differential reactivity. The carbon-bromine bond is generally more reactive towards nucleophilic substitution and organometallic formation (like Grignard reagents) compared to the carbon-fluorine bond. This means chemists can selectively functionalize the molecule at the bromine site while retaining the fluorine atom for later modification or as a stable substituent in the final product.

Common Synthetic Transformations

Researchers often explore the following reactions when using 1-Bromo-4-fluorobutane:

  • Nucleophilic Substitution: Reacting with nucleophiles like amines, alkoxides, or thiols to introduce new functional groups. For example, reacting with an amine would yield a 4-fluoro-N-alkylbutan-1-amine. This is a fundamental reaction for building more complex structures.
  • Grignard Reagent Formation: Treating with magnesium metal to form the corresponding Grignard reagent, 4-fluorobutylmagnesium bromide. This organometallic species can then react with electrophiles such as aldehydes, ketones, or esters, extending the carbon chain.
  • Organolithium Formation: Similar to Grignard formation, treatment with organolithium reagents can generate 4-fluorobutyllithium, offering another route to reactive intermediates.
  • Coupling Reactions: Utilizing palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) at the bromine site to form new carbon-carbon bonds with various partners.

These transformations make 1-Bromo-4-fluorobutane an excellent starting material for creating substituted alkanes, functionalized heterocycles, and more complex organic frameworks. Researchers looking to buy 1-bromo-4-fluorobutane for laboratory synthesis should ensure they source from reputable suppliers who guarantee high purity (e.g., ≥99.0%), as impurities can significantly affect reaction yields and product purity.

Efficient Lab Sourcing Strategies

For laboratory use, purchasing smaller quantities (grams to kilograms) is common. When searching for a CAS 462-72-6 supplier, consider suppliers that cater to research needs, offering convenient packaging and quick delivery. Exploring online platforms or chemical directories can help identify various options, including those that specialize in fine chemicals and intermediates. It’s beneficial to compare the 1-bromo-4-fluorobutane price from different sources and inquire about their technical support capabilities. For academic researchers, understanding the availability from manufacturers in regions like China, which offer competitive pricing, can be a significant advantage. Always ask for the Certificate of Analysis to confirm the product meets your research requirements.

By understanding its reactivity and sourcing it effectively, researchers can confidently incorporate 1-Bromo-4-fluorobutane into their synthetic endeavors, advancing scientific discovery.