For chemists and researchers engaged in advanced organic synthesis, understanding the fundamental properties and synthetic routes of key intermediates is paramount. 3-Chloro-5-(trifluoromethyl)pyridine (CAS: 85148-26-1) is a compound of significant interest due to its versatile reactivity and applications in pharmaceuticals, agrochemicals, and material science. This article, brought to you by a dedicated manufacturer and supplier in China, explores its chemical characteristics and common synthesis pathways.

Physical and Chemical Properties

3-Chloro-5-(trifluoromethyl)pyridine typically presents as an off-white crystalline powder. Its molecular formula is C6H3ClF3N, with a molecular weight of approximately 181.54 g/mol. Key reported physical properties include:

  • Density: Around 1.4 g/cm³ (±0.1)
  • Boiling Point: Approximately 146.0 °C at 760 mmHg (±35.0 °C)
  • Flash Point: Around 42.1 °C (±25.9 °C), indicating it is a combustible material.
  • Vapor Pressure: Roughly 6.0 mmHg at 25°C.
  • Index of Refraction: Around 1.447.

Chemically, the pyridine ring provides a stable aromatic system, while the chlorine atom offers a site for nucleophilic substitution or cross-coupling reactions. The electron-withdrawing trifluoromethyl group significantly influences the electronic distribution of the ring, impacting its reactivity and the properties of derivatives synthesized from it.

Common Synthesis Pathways

The industrial synthesis of 3-Chloro-5-(trifluoromethyl)pyridine often involves targeted halogenation and trifluoromethylation. One common approach involves the chlorination of pyridine derivatives. For instance, catalytic vapor-phase reactions using chlorine gas and specific catalysts can yield the desired product with good regioselectivity. The process typically requires controlled temperatures (e.g., 200–250°C) and careful management of reactant ratios to maximize yield and minimize unwanted byproducts, such as isomers chlorinated at different positions on the pyridine ring.

Another method might involve starting with a precursor already containing the trifluoromethyl group and then introducing the chlorine atom. The choice of catalyst (e.g., activated carbon, metal chlorides like FeCl₃) and reaction conditions are critical for achieving the desired selectivity for the 3-position, especially given the deactivating effect of the trifluoromethyl group at certain positions.

Quality and Reliability from Our Manufacturing Facility

As a manufacturer in China, we adhere to rigorous production standards to ensure the high purity (≥98.0%) and consistent quality of our 3-Chloro-5-(trifluoromethyl)pyridine. Our synthetic processes are optimized for efficiency and yield, allowing us to offer competitive prices for bulk purchase inquiries. We understand the importance of reliable chemical supply for research and industrial applications.

If you require this intermediate for your organic synthesis projects, our team is ready to provide you with detailed specifications, technical data, and a quotation. We are committed to being a trusted supplier, ensuring you receive a high-quality product that meets your exact needs. Contact us today to learn more about buying 3-Chloro-5-(trifluoromethyl)pyridine.