Fmoc-Ser(tBu)-OH: A Cornerstone for Custom Peptide Synthesis
The field of custom peptide synthesis has exploded in recent years, driven by the demand for highly specific peptides for therapeutic, diagnostic, and research purposes. At the heart of this process lies a suite of specialized reagents, among which Fmoc-protected amino acids are paramount. Fmoc-Ser(tBu)-OH, a protected form of serine, plays a pivotal role in enabling the efficient and accurate construction of complex peptide sequences.
Fmoc-Ser(tBu)-OH (Nα-Fmoc-O-tert-butyl-L-serine) is a key building block for researchers engaged in custom peptide manufacturing. Its utility stems from the strategic placement of protecting groups. The N-terminal Fmoc group is readily cleaved under basic conditions, allowing sequential addition of amino acids. Simultaneously, the tert-butyl group on the serine side chain's hydroxyl function prevents premature reactions, such as esterification or phosphorylation, during the synthesis process. This targeted protection ensures that only the desired peptide bonds are formed, leading to high-purity products.
When you choose to buy Fmoc-Ser(tBu)-OH, opting for a supplier that emphasizes high purity (often above 99%) is critical. The CAS number, 71989-33-8, serves as a unique identifier for this vital chemical. Access to reliable, high-quality Fmoc-Ser(tBu)-OH is essential for researchers aiming to produce peptides for sensitive applications, including drug development and biological assays. Suppliers often provide detailed Certificates of Analysis (CoA) that confirm the purity and identity of the compound.
The versatility of Fmoc-Ser(tBu)-OH extends to its compatibility with various peptide synthesis techniques, most notably solid-phase peptide synthesis (SPPS). It is a standard reagent for incorporating serine, an amino acid known for its role in protein folding and enzymatic activity, into peptide chains. The ease with which the tert-butyl protecting group can be removed during the final cleavage step further enhances its utility.
For those involved in custom peptide synthesis, securing a dependable source of Fmoc-Ser(tBu)-OH is a strategic imperative. Partnering with experienced manufacturers, such as those in China, ensures a consistent supply of this high-grade amino acid derivative. NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing researchers with the essential chemical reagents needed to drive innovation in peptide science.
Fmoc-Ser(tBu)-OH (Nα-Fmoc-O-tert-butyl-L-serine) is a key building block for researchers engaged in custom peptide manufacturing. Its utility stems from the strategic placement of protecting groups. The N-terminal Fmoc group is readily cleaved under basic conditions, allowing sequential addition of amino acids. Simultaneously, the tert-butyl group on the serine side chain's hydroxyl function prevents premature reactions, such as esterification or phosphorylation, during the synthesis process. This targeted protection ensures that only the desired peptide bonds are formed, leading to high-purity products.
When you choose to buy Fmoc-Ser(tBu)-OH, opting for a supplier that emphasizes high purity (often above 99%) is critical. The CAS number, 71989-33-8, serves as a unique identifier for this vital chemical. Access to reliable, high-quality Fmoc-Ser(tBu)-OH is essential for researchers aiming to produce peptides for sensitive applications, including drug development and biological assays. Suppliers often provide detailed Certificates of Analysis (CoA) that confirm the purity and identity of the compound.
The versatility of Fmoc-Ser(tBu)-OH extends to its compatibility with various peptide synthesis techniques, most notably solid-phase peptide synthesis (SPPS). It is a standard reagent for incorporating serine, an amino acid known for its role in protein folding and enzymatic activity, into peptide chains. The ease with which the tert-butyl protecting group can be removed during the final cleavage step further enhances its utility.
For those involved in custom peptide synthesis, securing a dependable source of Fmoc-Ser(tBu)-OH is a strategic imperative. Partnering with experienced manufacturers, such as those in China, ensures a consistent supply of this high-grade amino acid derivative. NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing researchers with the essential chemical reagents needed to drive innovation in peptide science.
Perspectives & Insights
Core Pioneer 24
“Fmoc-Ser(tBu)-OH (Nα-Fmoc-O-tert-butyl-L-serine) is a key building block for researchers engaged in custom peptide manufacturing.”
Silicon Explorer X
“The N-terminal Fmoc group is readily cleaved under basic conditions, allowing sequential addition of amino acids.”
Quantum Catalyst AI
“Simultaneously, the tert-butyl group on the serine side chain's hydroxyl function prevents premature reactions, such as esterification or phosphorylation, during the synthesis process.”