Understanding Fmoc-Ser(tBu)-OH: Purity, CAS, and Sourcing for Synthesis
In the intricate world of peptide synthesis, precision and purity are non-negotiable. Researchers rely on a carefully curated selection of reagents to build complex peptide molecules with desired functionalities. Among these, Fmoc-Ser(tBu)-OH stands out as a fundamental building block, particularly for solid-phase peptide synthesis (SPPS) employing the Fmoc strategy. Understanding its properties and sourcing is key to successful peptide production.
Fmoc-Ser(tBu)-OH, also known as Nα-Fmoc-O-tert-butyl-L-serine, is a derivative of the amino acid serine. Its chemical structure features the N-terminal Fmoc protecting group, which is sensitive to basic conditions, and a tert-butyl ether protecting group on the side-chain hydroxyl. This dual protection system is crucial: the Fmoc group allows for controlled, stepwise addition of amino acids, while the tert-butyl group shields the serine side chain from unwanted reactions during the synthesis process.
The importance of purity cannot be overstated when you buy Fmoc-Ser(tBu)-OH. High-purity grades, typically exceeding 99%, are essential to prevent side reactions and ensure the integrity of the synthesized peptide. Researchers often look for a reliable supplier that provides comprehensive documentation, including a Certificate of Analysis (CoA), confirming the compound's identity and purity. The CAS number 71989-33-8 is a universal identifier that helps in accurately sourcing this specific chemical.
The primary application of Fmoc-Ser(tBu)-OH is in the synthesis of peptides where serine residues are required. Serine's hydroxyl group can participate in crucial interactions within a peptide, influencing its structure and biological activity. By using the Fmoc/tBu strategy, researchers can reliably incorporate serine into peptide sequences, whether for therapeutic development, academic research, or custom peptide manufacturing. The tert-butyl protecting group is easily removed during the final peptide cleavage step, typically using strong acids like trifluoroacetic acid (TFA), without damaging the peptide chain.
For laboratories requiring this essential reagent, sourcing from reputable manufacturers is paramount. Companies specializing in fine chemical intermediates, especially those with a strong presence in China, can offer high-quality Fmoc-Ser(tBu)-OH at competitive prices. NINGBO INNO PHARMCHEM CO.,LTD. is a trusted provider committed to supplying researchers with the premium chemical building blocks necessary for advancing scientific discovery.
Fmoc-Ser(tBu)-OH, also known as Nα-Fmoc-O-tert-butyl-L-serine, is a derivative of the amino acid serine. Its chemical structure features the N-terminal Fmoc protecting group, which is sensitive to basic conditions, and a tert-butyl ether protecting group on the side-chain hydroxyl. This dual protection system is crucial: the Fmoc group allows for controlled, stepwise addition of amino acids, while the tert-butyl group shields the serine side chain from unwanted reactions during the synthesis process.
The importance of purity cannot be overstated when you buy Fmoc-Ser(tBu)-OH. High-purity grades, typically exceeding 99%, are essential to prevent side reactions and ensure the integrity of the synthesized peptide. Researchers often look for a reliable supplier that provides comprehensive documentation, including a Certificate of Analysis (CoA), confirming the compound's identity and purity. The CAS number 71989-33-8 is a universal identifier that helps in accurately sourcing this specific chemical.
The primary application of Fmoc-Ser(tBu)-OH is in the synthesis of peptides where serine residues are required. Serine's hydroxyl group can participate in crucial interactions within a peptide, influencing its structure and biological activity. By using the Fmoc/tBu strategy, researchers can reliably incorporate serine into peptide sequences, whether for therapeutic development, academic research, or custom peptide manufacturing. The tert-butyl protecting group is easily removed during the final peptide cleavage step, typically using strong acids like trifluoroacetic acid (TFA), without damaging the peptide chain.
For laboratories requiring this essential reagent, sourcing from reputable manufacturers is paramount. Companies specializing in fine chemical intermediates, especially those with a strong presence in China, can offer high-quality Fmoc-Ser(tBu)-OH at competitive prices. NINGBO INNO PHARMCHEM CO.,LTD. is a trusted provider committed to supplying researchers with the premium chemical building blocks necessary for advancing scientific discovery.
Perspectives & Insights
Silicon Analyst 88
“Fmoc-Ser(tBu)-OH, also known as Nα-Fmoc-O-tert-butyl-L-serine, is a derivative of the amino acid serine.”
Quantum Seeker Pro
“Its chemical structure features the N-terminal Fmoc protecting group, which is sensitive to basic conditions, and a tert-butyl ether protecting group on the side-chain hydroxyl.”
Bio Reader 7
“This dual protection system is crucial: the Fmoc group allows for controlled, stepwise addition of amino acids, while the tert-butyl group shields the serine side chain from unwanted reactions during the synthesis process.”