Fmoc-Ser(tBu)-OH: Essential Reagent for High-Quality Peptide Synthesis
The synthesis of peptides, whether for pharmaceutical applications, research, or cosmetic formulations, demands precision and the use of high-quality chemical reagents. Among these, protected amino acids are indispensable, and Fmoc-Ser(tBu)-OH is a prime example of a critical building block. This N-terminally protected serine derivative is fundamental to the Fmoc strategy in solid-phase peptide synthesis (SPPS), a widely adopted method for creating peptide chains.
Fmoc-Ser(tBu)-OH, chemically known as Nα-Fmoc-O-tert-butyl-L-serine, combines two crucial protecting groups. The Fmoc group safeguards the alpha-amino terminus and is removed via base treatment, enabling the iterative addition of amino acids. The tert-butyl (tBu) group is attached to the hydroxyl side chain of serine. This side-chain protection is vital as it prevents unwanted reactions, such as acylation or alkylation, during the various stages of peptide assembly, ensuring that the peptide chain grows with the desired sequence and integrity.
When researchers are looking to buy Fmoc-Ser(tBu)-OH, the emphasis is always on purity and reliability. High-grade Fmoc-Ser(tBu)-OH, typically with a purity exceeding 99%, is essential for minimizing side products and maximizing the yield of the target peptide. The CAS number 71989-33-8 serves as a unique identifier for this compound, facilitating its procurement from specialized chemical suppliers. Access to detailed product specifications and Certificates of Analysis (CoA) is a hallmark of trustworthy vendors.
The application of Fmoc-Ser(tBu)-OH is extensive in custom peptide manufacturing and drug discovery. Serine is a versatile amino acid often involved in enzyme active sites or post-translational modifications. Its accurate incorporation using protected derivatives like Fmoc-Ser(tBu)-OH is crucial for producing peptides with specific biological activities. The tert-butyl protecting group is selected for its compatibility with the final cleavage step, where it is efficiently removed under acidic conditions along with other protecting groups.
For scientists and chemists aiming for reproducible and successful peptide synthesis, sourcing high-quality Fmoc-Ser(tBu)-OH is non-negotiable. Collaborating with established manufacturers and suppliers, particularly those with a strong presence in the global market such as those in China, ensures access to these vital reagents. NINGBO INNO PHARMCHEM CO.,LTD. is a provider dedicated to supplying the chemical building blocks that empower advancements in peptide science and related industries.
Fmoc-Ser(tBu)-OH, chemically known as Nα-Fmoc-O-tert-butyl-L-serine, combines two crucial protecting groups. The Fmoc group safeguards the alpha-amino terminus and is removed via base treatment, enabling the iterative addition of amino acids. The tert-butyl (tBu) group is attached to the hydroxyl side chain of serine. This side-chain protection is vital as it prevents unwanted reactions, such as acylation or alkylation, during the various stages of peptide assembly, ensuring that the peptide chain grows with the desired sequence and integrity.
When researchers are looking to buy Fmoc-Ser(tBu)-OH, the emphasis is always on purity and reliability. High-grade Fmoc-Ser(tBu)-OH, typically with a purity exceeding 99%, is essential for minimizing side products and maximizing the yield of the target peptide. The CAS number 71989-33-8 serves as a unique identifier for this compound, facilitating its procurement from specialized chemical suppliers. Access to detailed product specifications and Certificates of Analysis (CoA) is a hallmark of trustworthy vendors.
The application of Fmoc-Ser(tBu)-OH is extensive in custom peptide manufacturing and drug discovery. Serine is a versatile amino acid often involved in enzyme active sites or post-translational modifications. Its accurate incorporation using protected derivatives like Fmoc-Ser(tBu)-OH is crucial for producing peptides with specific biological activities. The tert-butyl protecting group is selected for its compatibility with the final cleavage step, where it is efficiently removed under acidic conditions along with other protecting groups.
For scientists and chemists aiming for reproducible and successful peptide synthesis, sourcing high-quality Fmoc-Ser(tBu)-OH is non-negotiable. Collaborating with established manufacturers and suppliers, particularly those with a strong presence in the global market such as those in China, ensures access to these vital reagents. NINGBO INNO PHARMCHEM CO.,LTD. is a provider dedicated to supplying the chemical building blocks that empower advancements in peptide science and related industries.
Perspectives & Insights
Nano Explorer 01
“High-grade Fmoc-Ser(tBu)-OH, typically with a purity exceeding 99%, is essential for minimizing side products and maximizing the yield of the target peptide.”
Data Catalyst One
“The CAS number 71989-33-8 serves as a unique identifier for this compound, facilitating its procurement from specialized chemical suppliers.”
Chem Thinker Labs
“Access to detailed product specifications and Certificates of Analysis (CoA) is a hallmark of trustworthy vendors.”