Difluorophenacyl chloride, chemically known as 2-Chloro-1-(3,4-difluoro-phenyl)-ethanone (CAS 51336-95-9), is a compound of significant interest in contemporary chemical research and development. Its molecular structure, featuring a chlorinated acetyl group attached to a difluorinated benzene ring, endows it with reactivity that is highly prized in various synthetic transformations. This makes it a sought-after reagent for chemists engaged in the creation of complex organic molecules.

A primary area where this compound finds extensive application is in the field of pharmaceutical research. Its presence as a potential impurity in certain drug synthesis pathways necessitates its use as a reference standard for analytical chemists. By having access to high-purity 2-Chloro-1-(3,4-difluoro-phenyl)-ethanone, researchers can develop and validate analytical methods to detect and quantify this impurity, thereby ensuring the safety and efficacy of pharmaceutical products. The accurate identification and control of such impurities are paramount in drug development.


Beyond its role as a pharmaceutical impurity marker, difluorophenacyl chloride is a valuable building block in broader organic synthesis. Its functional groups allow for a range of reactions, including nucleophilic substitutions and condensation reactions, making it a versatile starting material. For instance, it plays a role in the synthesis of specific cyclopropane derivatives, which are important structural motifs found in numerous biologically active compounds. The ability to efficiently synthesize these structures using CAS 51336-95-9 contributes to the development of new therapeutics and fine chemicals.


Sourcing this chemical intermediate from reliable manufacturers is crucial for researchers and companies. China, with its robust chemical manufacturing sector, offers numerous suppliers for 2-Chloro-1-(3,4-difluoro-phenyl)-ethanone. Ensuring the quality and consistent supply of this compound is key to the success of research projects and production scaling. The properties of this compound, such as its appearance as a light yellow solid, and its lachrymatory nature, require careful handling protocols to ensure laboratory safety.


In summary, the applications of difluorophenacyl chloride are multifaceted. Its importance as a pharmaceutical impurity standard and its utility as a versatile reagent in organic synthesis highlight its critical role in the chemical landscape. For anyone involved in drug discovery, process development, or the synthesis of specialized organic molecules, understanding and procuring 2-Chloro-1-(3,4-difluoro-phenyl)-ethanone (CAS 51336-95-9) is a vital step.