In the realm of specialized chemicals, intermediates are the backbone of innovation, enabling the synthesis of complex molecules. 2-Chloro-1-(3,4-difluoro-phenyl)-ethanone, bearing the CAS number 51336-95-9, is a prime example of such a critical intermediate. Its unique molecular architecture makes it a valuable tool for chemists across various disciplines, from organic synthesis to pharmaceutical development.

The compound's chemical formula, C8H5ClF2O, reveals its structure: an acetophenone derivative with two fluorine atoms and a chlorine atom strategically placed. This fluorination often imparts enhanced stability and altered electronic properties to molecules derived from it, which is highly desirable in many applications. The presence of the reactive chlorine atom also makes it amenable to various substitution reactions, expanding its synthetic utility. The synthesis of this compound typically involves the reaction of 1,2-difluorobenzene with chloroacetyl chloride, a process that demands precise control over reaction parameters to achieve high yields and purity.


As an organic synthesis intermediate, 2-Chloro-1-(3,4-difluoro-phenyl)-ethanone is instrumental in creating a diverse range of downstream products. It is particularly noted for its use in the preparation of cyclopropane derivatives, which are structural motifs commonly found in pharmaceuticals. The ability to efficiently synthesize these complex structures using this intermediate streamlines research and development efforts. Moreover, its role as a pharmaceutical impurity means it is also utilized as a reference standard for analytical testing, crucial for drug quality control.


For those looking to procure this chemical, the market offers numerous options, with many suppliers located in China providing high-quality grades. When purchasing, it is important to consider factors such as purity levels, safety data sheets (SDS), and the supplier's adherence to quality management systems. The lachrymatory nature of the compound also dictates the need for careful handling and appropriate safety equipment in any laboratory or manufacturing setting.


The continuous exploration and application of chemical intermediates like 2-Chloro-1-(3,4-difluoro-phenyl)-ethanone are vital for advancing scientific knowledge and developing new products. Whether for research experiments or large-scale production, understanding the chemistry, synthesis, and applications of CAS 51336-95-9 ensures its effective and safe utilization in the ever-evolving chemical industry.