2-Chloro-1-(3,4-difluoro-phenyl)-ethanone, identified by its CAS number 51336-95-9, is a compound that holds significant value within the chemical industry, particularly as an intermediate in organic synthesis. A thorough understanding of its properties and synthesis is essential for its effective utilization.

Physically, this compound typically presents as a light yellow solid. Its melting point is generally reported in the range of 31-33°C, indicating it is a solid at standard room temperatures. The boiling point is approximately 256.3°C, though this can vary slightly with pressure. Its density is around 1.353 g/cm³. Due to its lachrymatory nature, appropriate safety precautions, including the use of personal protective equipment and adequate ventilation, are mandatory when handling this chemical.


The synthesis of 2-Chloro-1-(3,4-difluoro-phenyl)-ethanone commonly involves the Friedel-Crafts acylation reaction. A typical route involves reacting 1,2-difluorobenzene with chloroacetyl chloride in the presence of a Lewis acid catalyst, such as aluminum trichloride. The process requires careful control of reaction temperature and conditions to maximize yield and purity. Post-reaction work-up usually involves quenching with water or ice, extraction with an organic solvent, washing, drying, and often distillation under reduced pressure to isolate the final product. Understanding these 2-chloro-1-(3,4-difluoro-phenyl)-ethanone synthesis steps is crucial for industrial production.


As a key organic synthesis intermediate, CAS 51336-95-9 serves as a precursor for a variety of valuable compounds. It is particularly important in the preparation of difluorophenyl derivatives, including specific cyclopropane structures that are foundational in many pharmaceutical agents. Its role as a pharmaceutical impurity also means that its controlled synthesis and availability are vital for quality assurance in drug manufacturing.


For researchers and manufacturers seeking this compound, sourcing from reliable suppliers, especially those in China, is a common practice. Purchasing from established manufacturers ensures that the product meets the required purity specifications for demanding applications. Whether you are looking to buy this chemical for laboratory research or industrial scaling, understanding its properties and synthesis pathways is the first step toward successful integration into your chemical processes.