N-Phenyl-bis(trifluoromethanesulfonimide): A Key Reagent for Modern Synthetic Chemistry
The efficiency and selectivity of chemical reactions are crucial for advancing scientific research and industrial applications. N-Phenyl-bis(trifluoromethanesulfonimide), commonly identified by its CAS number 37595-74-7, has established itself as an indispensable reagent in modern synthetic organic chemistry. NINGBO INNO PHARMCHEM CO.,LTD. is a proud provider of this vital compound, enabling breakthroughs in fields ranging from pharmaceuticals to materials science.
The principal role of N-Phenyl-bis(trifluoromethanesulfonimide) is as a mild and effective triflating agent. It facilitates the introduction of the trifluoromethanesulfonyl (triflyl) group onto various molecules, transforming them into more reactive species. This triflyl group is an excellent leaving group, making it ideal for activating substrates for subsequent nucleophilic substitution or cross-coupling reactions. Its application in preparing triflates from phenols, amines, and carbonyl compounds (leading to enol triflates) is particularly noteworthy. Researchers often seek to buy N-Phenyl-bis(trifluoromethanesulfonimide) for its reliability and versatility.
The enol triflates derived from carbonyl compounds using N-Phenyl-bis(trifluoromethanesulfonimide) are pivotal in constructing complex molecular frameworks. These intermediates readily participate in palladium-catalyzed cross-coupling reactions, such as Suzuki, Stille, and Heck couplings, allowing for the formation of new carbon-carbon bonds. This capability is fundamental in the synthesis of intricate organic molecules, including biologically active compounds and advanced functional materials. The consistent availability of this reagent from a trusted supplier of N-Phenyl-bis(trifluoromethanesulfonimide) is crucial for maintaining research momentum.
Moreover, N-Phenyl-bis(trifluoromethanesulfonimide) serves as a valuable tool for synthesizing triflones and for modifying functional groups within molecules. Its mild reaction conditions ensure that it can be employed with a wide array of substrates, including those that are sensitive to harsher reagents. This makes it a highly adaptable reagent for various synthetic strategies. The competitive price of N-Phenyl-bis(trifluoromethanesulfonimide) further contributes to its widespread use in research and development.
NINGBO INNO PHARMCHEM CO.,LTD. is committed to supporting the chemical industry by supplying high-quality reagents that drive innovation. N-Phenyl-bis(trifluoromethanesulfonimide) is a testament to this commitment, providing chemists with a powerful tool for creating novel compounds and processes. Whether for academic exploration or industrial production, this triflating agent offers significant advantages for tackling demanding synthetic challenges.
Perspectives & Insights
Chem Catalyst Pro
“It facilitates the introduction of the trifluoromethanesulfonyl (triflyl) group onto various molecules, transforming them into more reactive species.”
Agile Thinker 7
“This triflyl group is an excellent leaving group, making it ideal for activating substrates for subsequent nucleophilic substitution or cross-coupling reactions.”
Logic Spark 24
“Its application in preparing triflates from phenols, amines, and carbonyl compounds (leading to enol triflates) is particularly noteworthy.”