N-Phenyl-bis(trifluoromethanesulfonimide): Enhancing Synthesis with Powerful Triflation
In the dynamic field of organic synthesis, reagents that offer both efficiency and selectivity are highly prized. N-Phenyl-bis(trifluoromethanesulfonimide), known scientifically by its CAS number 37595-74-7, is a prominent example of such a reagent, widely utilized for its potent triflating capabilities. NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to supplying this essential chemical to researchers and industries worldwide.
The core utility of N-Phenyl-bis(trifluoromethanesulfonimide) lies in its function as a mild yet highly effective triflating agent. This allows for the precise introduction of the trifluoromethanesulfonyl (triflyl) group onto various organic molecules. The triflate anion, formed when the triflyl group departs, is an exceptional leaving group. This property makes it instrumental in activating molecules for subsequent chemical transformations, especially in the synthesis of enol triflates from carbonyl compounds and the triflation of phenols and amines. The stability and ease of handling associated with N-Phenyl-bis(trifluoromethanesulfonimide) make it a preferred choice for many synthetic chemists looking to buy this compound.
The enol triflates prepared using N-Phenyl-bis(trifluoromethanesulfonimide) are indispensable intermediates in a multitude of carbon-carbon bond-forming reactions. These include palladium-catalyzed cross-coupling methodologies such as the Suzuki, Stille, and Heck reactions. The ability to generate these activated intermediates efficiently using N-Phenyl-bis(trifluoromethanesulfonimide) opens up broad avenues for the construction of complex molecular structures, which are essential for drug discovery, materials science, and natural product synthesis. Accessing this reagent from a reliable supplier like NINGBO INNO PHARMCHEM CO.,LTD. ensures the quality required for these sensitive transformations.
Beyond its primary role in triflation, N-Phenyl-bis(trifluoromethanesulfonimide) also contributes to the synthesis of triflones and facilitates various functional group modifications. Its mild reaction conditions are advantageous when dealing with delicate substrates that might be susceptible to degradation under more vigorous conditions. This versatility, coupled with the accessible price point, makes it an attractive option for a wide range of research projects and industrial processes.
NINGBO INNO PHARMCHEM CO.,LTD. is committed to empowering scientific advancement by providing top-tier chemical reagents. N-Phenyl-bis(trifluoromethanesulfonimide) exemplifies this commitment, offering chemists a powerful tool to enhance the efficiency and scope of their synthetic endeavors. By ensuring a consistent supply of this vital triflating agent, we contribute to the progress of chemical innovation.
Perspectives & Insights
Chem Catalyst Pro
“In the dynamic field of organic synthesis, reagents that offer both efficiency and selectivity are highly prized.”
Agile Thinker 7
“N-Phenyl-bis(trifluoromethanesulfonimide), known scientifically by its CAS number 37595-74-7, is a prominent example of such a reagent, widely utilized for its potent triflating capabilities.”
Logic Spark 24
“is dedicated to supplying this essential chemical to researchers and industries worldwide.”