N-Phenyl-bis(trifluoromethanesulfonimide): A Versatile Triflation Reagent for Organic Synthesis
Discover the key properties and applications of this essential chemical tool in modern synthesis.
Get a Quote & SampleProduct Core Value
N-Phenyl-bis(trifluoromethanesulfonimide)
This compound is a stable, crystalline, and easy-to-handle mild triflating agent. It is highly effective for the triflation of phenols and amines, particularly aliphatic secondary amines. Its utility extends to the preparation of triflones and the generation of enol triflates from carbonyl compounds, making it a cornerstone reagent for various synthetic transformations.
- This mild triflating reagent is excellent for the triflation of phenols and amines, offering a cleaner reaction profile in many organic synthesis applications.
- The preparation of triflates from carbonyl compounds is significantly aided by this reagent, enabling key steps in complex molecular construction.
- As a stable and easy-to-handle compound, it simplifies laboratory procedures and enhances safety in chemical research.
- Its role in forming activated intermediates for coupling reactions, such as Suzuki and Stille, highlights its importance in building sophisticated molecular architectures.
Key Advantages
Mild Triflation Capabilities
Experience efficient and selective triflation of sensitive substrates, crucial for achieving desired outcomes in complex organic synthesis.
Enhanced Reactivity in Coupling Reactions
Utilize this reagent to generate activated intermediates that readily participate in palladium-catalyzed coupling reactions, expanding synthetic possibilities.
Ease of Handling and Stability
Benefit from a reagent that is stable and easy to handle, reducing complications and improving the overall efficiency of your research processes.
Key Applications
Phenol and Amine Triflation
A primary use involves the selective triflation of phenols and amines, a critical step in many organic synthesis pathways.
Enol Triflate Synthesis
Efficiently prepare enol triflates from carbonyl compounds, enabling further transformations and the construction of intricate molecules.
Cross-Coupling Reactions
Serve as a precursor for activated intermediates in Stille, Suzuki, and other cross-coupling reactions, facilitating carbon-carbon bond formation.
Pharmaceutical Intermediates
Its role in synthesizing complex molecules makes it valuable as an intermediate in the pharmaceutical industry for drug development.