For chemists and R&D professionals engaged in organic synthesis, a deep understanding of the chemical profile of intermediates is foundational to successful experimentation and product development. 2,4,6-Trimethylbenzoyl chloride (CAS 938-18-1) is one such compound, offering a unique combination of structure and reactivity that makes it a valuable tool in the synthetic chemist's arsenal. As a leading provider of fine chemicals, NINGBO INNO PHARMCHEM CO.,LTD. is committed to supplying high-quality materials backed by thorough technical information.

Chemical Structure and Key Properties

2,4,6-Trimethylbenzoyl chloride, with the molecular formula C10H11ClO and a molecular weight of 182.65 g/mol, is characterized by a benzoyl chloride structure substituted with three methyl groups at the 2, 4, and 6 positions of the aromatic ring. This steric bulk from the methyl groups influences its reactivity and stability. Typically appearing as a clear to light yellow liquid, it possesses a boiling point of approximately 143-146 °C at 60 mmHg and a density of 1.095 g/mL at 25 °C. Its sensitive nature to moisture requires careful handling and storage, often at 2-8°C, to maintain its integrity. The presence of the acyl chloride functional group (-COCl) makes it highly reactive towards nucleophiles, facilitating esterification and amidation reactions, critical steps in many synthetic routes.

Insights into Synthesis and Reactivity

The synthesis of 2,4,6-Trimethylbenzoyl chloride commonly involves the conversion of its corresponding carboxylic acid, 2,4,6-trimethylbenzoic acid, using chlorinating agents such as thionyl chloride (SOCl2) or phosphorus pentachloride (PCl5). This established method ensures a reliable pathway for its production. In application, its reactivity as an acyl chloride is its defining characteristic. For instance, it is used to protect hydroxyl (-OH) groups by forming mesitoate esters. This protecting group strategy is widely employed in complex multi-step syntheses where selective functionalization is required. Understanding these synthetic routes and reactive behaviors is crucial for anyone looking to buy 2,4,6-Trimethylbenzoyl chloride for laboratory or industrial use.

Reliable Sourcing for Your Research Needs

Access to precise chemical information and reliable supply is vital for research and development. When you need to purchase 2,4,6-Trimethylbenzoyl chloride, partnering with a knowledgeable supplier like NINGBO INNO PHARMCHEM CO.,LTD. ensures you receive a product that meets your exact specifications. Our commitment to quality and customer service makes us a premier choice for chemists and researchers seeking high-purity intermediates for their demanding projects.