In the intricate world of organic synthesis, having access to versatile and reliable building blocks is fundamental for innovation. 1-Benzyl-4-hydroxypiperidine (CAS 4727-72-4) stands out as such a compound, offering unique structural features that make it highly valuable for chemists engaged in various research and development projects. As a readily available intermediate, understanding its chemical properties and synthetic utility can unlock new possibilities in material science and advanced chemical production.

Chemical Profile and Reactivity

With the chemical formula C12H17NO and a molecular weight of 191.27 g/mol, 1-Benzyl-4-hydroxypiperidine is characterized by a piperidine ring substituted with a benzyl group on the nitrogen atom and a hydroxyl group at the 4-position. This dual functionality—a tertiary amine and a secondary alcohol—confers significant reactivity and versatility. The hydroxyl group can participate in esterification, etherification, oxidation, and substitution reactions, while the nitrogen atom allows for quaternization and other reactions typical of tertiary amines. Its appearance as a white to off-white crystalline powder, with a melting point of 61-63°C, makes it relatively easy to handle and incorporate into synthetic workflows.

Applications in Chemical Research and Development

The primary application of 1-Benzyl-4-hydroxypiperidine lies in its role as an intermediate for pharmaceuticals. However, its utility extends into broader organic synthesis. Researchers employ it to construct more complex heterocyclic molecules, develop new catalysts, or as a component in the synthesis of specialty chemicals. For instance, its chiral potential, when appropriately derivatized, can be exploited in asymmetric synthesis. When you need to buy this versatile building block for your synthesis projects, seeking out suppliers who can provide detailed technical specifications and consistent quality is crucial. Purchasing from a reliable manufacturer ensures that your synthetic pathways are not compromised by substandard materials.

Procuring Quality Intermediates

For chemists and procurement managers, identifying a trustworthy manufacturer and supplier for 1-Benzyl-4-hydroxypiperidine is a key operational consideration. Companies looking to purchase this compound can benefit from the extensive chemical supply networks available, particularly from manufacturers and suppliers in China. Prioritizing suppliers who offer high purity (e.g., ≥98.0%) and timely delivery supports the efficiency of laboratory research and pilot-scale production. Engaging with these suppliers for quotes and bulk orders is a standard practice to secure a consistent and cost-effective supply of this essential organic synthesis tool.