For businesses operating in the pharmaceutical and fine chemical sectors, understanding the nuances of global chemical sourcing is critical. 1-Benzyl-4-hydroxypiperidine (CAS 4727-72-4) is a valuable intermediate whose procurement often leads buyers to explore international markets, particularly China, known for its extensive chemical manufacturing capabilities. This guide provides insights for buyers looking to purchase this compound, emphasizing quality, supplier reliability, and cost-effectiveness.

The Significance of 1-Benzyl-4-hydroxypiperidine in Synthesis

1-Benzyl-4-hydroxypiperidine is a key chemical intermediate with a molecular formula of C12H17NO and a molecular weight of 191.27 g/mol. It is typically presented as a white to off-white crystalline powder and is characterized by a high purity level, often ≥98.0%. Its structural features, including a hydroxyl group and a benzyl-protected amine, make it highly suitable for various organic synthesis reactions. Its primary application is as a precursor in the pharmaceutical industry, facilitating the synthesis of a range of medicinal compounds, including those that act on the central nervous system. Researchers also utilize it in general organic synthesis for creating complex molecules.

Quality Standards and Specifications to Look For

When sourcing 1-Benzyl-4-hydroxypiperidine, buyers must pay close attention to quality specifications. A purity of ≥98.0% is a standard benchmark, and a well-defined melting point (typically 61-63°C) indicates product integrity. It is essential to partner with manufacturers and suppliers who can consistently deliver material meeting these standards. Requesting Certificates of Analysis (COA) for each batch is a crucial step to verify product quality and ensure it aligns with the intended application, whether for R&D or large-scale production. Understanding the physical form, such as crystalline powder, also aids in handling and processing.

Navigating Procurement from China

China has emerged as a dominant global supplier of chemical intermediates, including 1-Benzyl-4-hydroxypiperidine. Buyers looking to purchase this compound can leverage the competitive pricing and vast manufacturing capacity available from Chinese suppliers. When initiating procurement, it's advisable to identify reputable manufacturers and trading companies that specialize in pharmaceutical intermediates. Engaging in direct communication to request detailed product specifications, inquire about bulk order discounts, and clarify lead times is essential. Building a relationship with a reliable Chinese supplier ensures a stable and cost-effective supply chain for this important chemical building block, supporting your ongoing projects and product development efforts.