Organic synthesis is the backbone of many modern industries, from pharmaceuticals and agrochemicals to materials science. At the heart of this field are versatile building blocks that enable the creation of complex molecules. Among these, 2-Bromo-1-(4-Chlorophenyl)Ethan-1-One, identified by CAS number 536-38-9, stands out for its utility and reactivity. This article highlights its properties, applications, and how to efficiently source it for your synthesis needs.

Understanding the Compound: 2-Bromo-1-(4-Chlorophenyl)Ethan-1-One

Also known by numerous synonyms including 4-Chlorophenacyl bromide and alpha-Bromo-4-chloroacetophenone, this compound (C8H6BrClO) is a halogenated acetophenone derivative. It typically presents as a white to pale yellow crystalline solid with a molecular weight of 233.49 g/mol. Its chemical structure, featuring an alpha-bromine atom adjacent to a carbonyl group and a para-chlorinated phenyl ring, makes it a highly reactive electrophile. This reactivity is key to its broad application in synthesis.

Key Applications in Organic Synthesis

The versatility of 2-Bromo-1-(4-Chlorophenyl)Ethan-1-One stems from its ability to undergo various chemical transformations. Its primary use is as an intermediate in the synthesis of fine chemicals and pharmaceuticals. It is instrumental in:

  • Nucleophilic Substitution Reactions: The alpha-bromine is readily displaced by various nucleophiles, allowing for the introduction of different functional groups.
  • Alkylation: It can be used to alkylate amines, thiols, and other nucleophilic species.
  • Synthesis of Heterocycles: It serves as a precursor for various heterocyclic compounds, which are prevalent in pharmaceuticals and agrochemicals.
  • Research and Development: A fundamental reagent in academic and industrial research laboratories for exploring new synthetic routes and developing novel compounds.

Sourcing Strategies for Procurement Professionals

For R&D scientists and procurement managers looking to buy 2-Bromo-1-(4-Chlorophenyl)Ethan-1-One, finding a reliable supplier with consistent quality and competitive pricing is essential. When sourcing this chemical, consider the following:

  • Manufacturer Location: Many high-quality and cost-effective options are available from Chinese manufacturers.
  • Purity Levels: Aim for products with a purity of ≥99.0% for critical synthesis steps. Always request and review the Certificate of Analysis (COA).
  • Supplier Capabilities: Look for suppliers who offer bulk pricing, custom synthesis services, and robust technical support.
  • Safety Information: Ensure you have access to the Safety Data Sheet (SDS) to understand proper handling, storage (often 2-8°C), and safety precautions, as it can be a lachrymator.
  • Market Research: Compare offers from multiple suppliers to secure the best price and delivery terms. Requesting a quote is a standard procedure.

By leveraging the reactivity and structural versatility of 2-Bromo-1-(4-Chlorophenyl)Ethan-1-One, chemists can develop innovative molecules and efficient synthetic pathways. Partnering with a trusted supplier ensures access to this indispensable building block, facilitating advancements in chemical research and industrial applications. Explore your purchasing options and secure this critical intermediate for your next project.