Navigating the complex landscape of chemical procurement requires a keen understanding of product specifications and reliable suppliers. For professionals in the pharmaceutical and fine chemical industries, sourcing high-purity 2-Bromo-4'-chloroacetophenone (CAS: 536-38-9) is paramount. This article serves as a comprehensive guide for procurement managers and R&D scientists looking to buy this critical intermediate.

Understanding the Product: 2-Bromo-4'-chloroacetophenone

2-Bromo-4'-chloroacetophenone, also known by synonyms such as 4-Chlorophenacyl bromide or alpha-Bromo-4-chloroacetophenone, is a key chemical building block. Its molecular formula is C8H6BrClO, with a molecular weight of approximately 233.49 g/mol. It typically appears as a white to light yellow solid, with a melting point range of 93-99°C. The compound's structure makes it highly reactive and valuable in various synthetic pathways.

Key Applications in Industry

The primary utility of 2-Bromo-4'-chloroacetophenone lies in its role as a pharmaceutical intermediate. It is essential in the synthesis of numerous active pharmaceutical ingredients (APIs) and has been noted as an intermediate for Tolvaptan. Beyond pharmaceuticals, it serves as a versatile reagent in organic synthesis for developing agrochemicals and other fine chemicals. Its ability to participate in nucleophilic substitution and coupling reactions makes it indispensable for creating complex molecular structures.

Where to Buy: Finding Reliable Manufacturers and Suppliers

When seeking to purchase 2-Bromo-4'-chloroacetophenone, identifying reputable manufacturers and suppliers is crucial for ensuring product quality and supply chain stability. Many global suppliers offer this chemical, with a significant number of manufacturers based in China. Buyers often look for suppliers that provide detailed product specifications, including purity levels (often specified as ≥99.0% or higher), CAS number confirmation (536-38-9), and comprehensive safety data sheets (SDS).

Procurement managers should inquire about pricing for different quantities, from laboratory-scale to bulk industrial orders. Companies often seek suppliers offering competitive pricing per kilogram or milligram, depending on their immediate needs. Furthermore, availability and lead times are critical factors, especially for projects with tight deadlines. Requesting a quote from multiple suppliers can help secure the best terms and ensure a consistent supply.

Purity and Quality Considerations

The purity of 2-Bromo-4'-chloroacetophenone directly impacts the success of downstream synthesis. High purity, such as 99% or greater, is often required for pharmaceutical applications to avoid unwanted side reactions and ensure the efficacy of the final product. Always verify the Certificate of Analysis (COA) provided by the manufacturer to confirm the specified purity and identify any potential impurities.

Factors to Consider for Your Purchase:

  • Manufacturer Reputation: Look for established manufacturers with a track record of quality and reliability.
  • Purity Level: Ensure the purity meets your specific application requirements (e.g., ≥99.0%).
  • Pricing: Compare prices from different suppliers for bulk and laboratory quantities. Request a detailed quote.
  • Availability and Lead Time: Confirm stock levels and delivery schedules, especially for urgent orders.
  • Documentation: Ensure the supplier provides SDS, COA, and other relevant regulatory documents.
  • Storage and Handling: Understand the recommended storage conditions (often 2-8°C in an inert atmosphere) and safety precautions.

By carefully considering these factors, businesses can confidently source high-quality 2-Bromo-4'-chloroacetophenone, ensuring the efficiency and success of their chemical synthesis and pharmaceutical development projects. Engage with trusted manufacturers and suppliers to secure your supply chain today.