For professionals in the pharmaceutical and fine chemical sectors, identifying and procuring high-quality intermediates is a cornerstone of successful operations. 3,4-Dihydroxy-5-nitrobenzaldehyde, known by its CAS number 116313-85-0, is a significant intermediate, primarily used in the synthesis of the Parkinson's disease medication, Entacapone. This guide is designed to assist buyers in their search for reliable suppliers of this essential chemical, emphasizing quality, consistency, and efficient procurement processes.

Key Specifications for 3,4-Dihydroxy-5-nitrobenzaldehyde

When a buyer looks to purchase 3,4-Dihydroxy-5-nitrobenzaldehyde, several critical specifications must be evaluated. The purity of the compound is paramount, with most reputable manufacturers offering an assay of ≥99.0%. This high purity is crucial for minimizing side reactions during complex synthesis pathways, like that of Entacapone, and ensuring the quality of the final Active Pharmaceutical Ingredient (API). Beyond purity, buyers should also look for detailed physical and chemical property data, including appearance (typically a yellowish powder), melting point, and solubility characteristics. A thorough Certificate of Analysis (COA) from the supplier is essential for validating these specifications and ensuring compliance with regulatory requirements.

Finding and Vetting Manufacturers and Suppliers

The global market hosts numerous chemical suppliers for 3,4-Dihydroxy-5-nitrobenzaldehyde. Identifying the right partner requires diligent research. Buyers often start by searching for “3,4-Dihydroxy-5-nitrobenzaldehyde suppliers” or “CAS 116313-85-0 manufacturer.” Geographical location can also be a factor, with many manufacturers based in China offering competitive pricing. When vetting potential suppliers, consider their years of experience, manufacturing certifications (e.g., ISO, GMP), customer testimonials, and their willingness to provide comprehensive technical documentation. Direct inquiries to manufacturers for quotations and product samples are standard practice to assess quality and suitability for your specific application.

Navigating the Purchase Process and Pricing

The procurement of 3,4-Dihydroxy-5-nitrobenzaldehyde involves understanding pricing structures and delivery logistics. Prices are typically quoted per kilogram or per batch and can vary based on order volume. Buyers should request detailed quotes that include product specifications, payment terms, and estimated delivery times. For large-scale production needs, establishing a long-term supply agreement with a trusted manufacturer can ensure price stability and consistent availability. If you are looking to buy this intermediate, a direct inquiry to a reputable manufacturer will provide the most accurate pricing and lead times.

Beyond Entacapone: Other Applications

While its primary role is as an Entacapone intermediate, 3,4-Dihydroxy-5-nitrobenzaldehyde can also serve other purposes. It may be utilized as an analytical reference standard for quality control in pharmaceutical laboratories or as a starting material for novel compound synthesis in research and development. Regardless of the application, the consistent quality and reliable supply from a reputable manufacturer are key for all users.

In summary, sourcing 3,4-Dihydroxy-5-nitrobenzaldehyde requires a focus on product purity, supplier reliability, and a clear understanding of the procurement process. By diligently vetting suppliers and understanding the critical specifications, buyers can secure this vital intermediate to support their manufacturing and research endeavors.