The pharmaceutical industry relies heavily on a complex network of chemical synthesis, where specific intermediates are indispensable for creating life-saving drugs. 4-Nitrobenzyl Hydrogen Malonate (CAS 77359-11-6) is one such critical compound, primarily used in the synthesis of powerful antibiotics.

Chemical Profile of 4-Nitrobenzyl Hydrogen Malonate

This organic chemical compound, with the formula C10H9NO6, presents as a white to almost white powder. Its melting point is a key characteristic, reliably recorded at 109°C. The compound exhibits good solubility in methanol, making it suitable for various reactions in organic synthesis. Its high purity, often specified at 99% or greater, is a testament to its suitability for pharmaceutical manufacturing, where stringent quality control is paramount.

Applications: Bridging to Antibiotic Synthesis

The primary application of 4-Nitrobenzyl Hydrogen Malonate is its role as a vital intermediate in the production of beta-lactam antibiotics. It is particularly crucial for the synthesis of (±)-thienamycin, a significant antibiotic, and also serves as a key chiral building block in the development of carbapenem antibiotics. These antibiotics are frontline treatments for severe bacterial infections, including those resistant to other drugs. Researchers and production managers depend on the consistent quality and availability of this intermediate to ensure the efficacy and success of their synthesis processes.

Sourcing and Supply Chain Considerations

For pharmaceutical companies looking to buy 4-Nitrobenzyl Hydrogen Malonate, identifying a reliable manufacturer and supplier is essential. China is a significant global source for such fine chemicals, offering competitive pricing and high-purity materials. When procuring this intermediate, it is important to work with suppliers who can provide comprehensive documentation, including Certificates of Analysis (CoA) and Material Safety Data Sheets (MSDS), ensuring compliance and quality assurance. A stable supply chain from a trusted source is critical for uninterrupted production cycles.

By understanding the properties and applications of 4-Nitrobenzyl Hydrogen Malonate, and by partnering with reputable suppliers, pharmaceutical manufacturers can effectively advance their antibiotic development and production efforts.