In the realm of chemical synthesis, certain molecules serve as indispensable linchpins, enabling the creation of a vast array of downstream products. 5-Bromoisophthalonitrile, identified by CAS number 160892-07-9, is precisely such a compound. This article aims to provide a comprehensive overview for procurement professionals and chemists, detailing its synthesis, diverse applications, and offering guidance on sourcing this vital intermediate, particularly from China.

Understanding 5-Bromoisophthalonitrile (CAS 160892-07-9)

5-Bromoisophthalonitrile is an organic compound characterized by a benzene ring substituted with two nitrile (-CN) groups at the 1 and 3 positions and a bromine (-Br) atom at the 5 position. Its molecular formula is C8H3BrN2, and it has a molecular weight of approximately 207.03 g/mol. Typically supplied as a solid, its purity (often 97% min) is a critical quality indicator for its performance in subsequent chemical reactions.

The structure of 5-Bromoisophthalonitrile confers significant chemical versatility. The nitrile groups can undergo reactions such as reduction to amines, hydrolysis to carboxylic acids, or participation in cycloaddition reactions. The bromine atom is highly reactive in cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) and nucleophilic aromatic substitution, making it an ideal synthon for constructing complex organic frameworks.

Synthesis Methods and Industrial Production

The industrial synthesis of 5-Bromoisophthalonitrile commonly involves the bromination of isophthalonitrile. Key methods include:

  • Direct Electrophilic Bromination: Using bromine in the presence of catalysts like iron(III) bromide (FeBr3) or aluminum chloride (AlCl3). Careful control of reaction conditions is necessary to achieve regioselectivity and minimize over-bromination.
  • N-Bromosuccinimide (NBS) Bromination: This method offers a more controlled and often safer alternative, frequently employed in polar solvents, sometimes with catalytic acid.
  • Sandmeyer Reaction: If starting from an appropriately substituted aniline precursor, the Sandmeyer reaction provides a pathway to introduce the nitrile groups or the bromine atom.

Manufacturers focus on optimizing these synthesis routes for scalability, cost-efficiency, and environmental sustainability, ensuring a consistent supply of high-purity material.

Key Applications Driving Demand

The utility of 5-Bromoisophthalonitrile spans multiple industries:

  • Pharmaceutical Intermediates: It is a foundational molecule for synthesizing a wide range of APIs and drug candidates, due to its ability to form complex molecular structures.
  • Agrochemicals: Its framework can be modified to create active ingredients for herbicides, pesticides, and fungicides, contributing to crop protection.
  • Advanced Materials: As a linker or monomer, it is crucial for the development of Metal-Organic Frameworks (MOFs) and Covalent Organic Frameworks (COFs), utilized in gas storage, catalysis, and separation technologies.
  • Organic Synthesis: A standard building block for researchers developing new synthetic methodologies and novel compounds.

Sourcing 5-Bromoisophthalonitrile from China

China has emerged as a global hub for fine chemical manufacturing, offering access to a wide array of intermediates at competitive prices. For businesses looking to buy 5-Bromoisophthalonitrile, partnering with reputable Chinese manufacturers and suppliers is a strategic advantage. NINGBO INNO PHARMCHEM CO.,LTD. is a professional chemical company that specializes in providing high-quality intermediates, including 5-Bromoisophthalonitrile.

Why Choose NINGBO INNO PHARMCHEM CO.,LTD.?

  • Quality Assurance: We ensure that the 5-Bromoisophthalonitrile we supply meets strict purity standards, critical for sensitive applications.
  • Competitive Manufacturer Pricing: By leveraging direct sourcing from manufacturers, we offer cost-effective solutions, especially for bulk orders. Obtain a quote to discuss your volume requirements.
  • Reliable Supply Chain: We are committed to providing a stable and consistent supply, ensuring that your projects are not hampered by material shortages.
  • Expert Support: Our knowledgeable team is available to assist with technical inquiries and provide excellent customer service.

For seamless procurement and high-quality materials, partner with NINGBO INNO PHARMCHEM CO.,LTD. We are your trusted source for 5-Bromoisophthalonitrile and other essential chemical intermediates. Contact us today to get a quote and learn more about how we can support your chemical sourcing needs.