For chemists and product developers, a thorough understanding of a chemical intermediate's synthesis routes and properties is fundamental to its effective application. 5'-Fluoro-2'-iodoacetophenone, identified by CAS 914225-70-0, is a prime example of such a crucial compound, particularly within the pharmaceutical sector. Its unique combination of functional groups—a ketone, a fluorine atom, and an iodine atom— dictates its reactivity and usefulness in complex organic synthesis. As a manufacturer, we offer this compound with detailed specifications and reliable production methods.

Synthesis Pathways for 5'-Fluoro-2'-iodoacetophenone

The preparation of 5'-Fluoro-2'-iodoacetophenone involves multi-step synthetic strategies. Common routes often begin with readily available aromatic precursors. One established method involves starting from 2-amino-5-fluorobenzoic acid. This precursor can undergo diazotization followed by iodination, and subsequent functional group transformations, including acylation, to introduce the acetyl group. Another pathway might utilize 5-fluoro-2-iodobenzoic acid, which can be converted to the corresponding acetophenone through reactions involving reagents like diethyl malonate and magnesium chloride. Each synthesis route requires careful control of reaction conditions, temperature, and reagent stoichiometry to achieve high yields and purity. Our manufacturing process is optimized for efficiency and consistent quality, ensuring a reliable supply for our customers.

Key Chemical Properties and Reactivity

5'-Fluoro-2'-iodoacetophenone exhibits distinct chemical properties derived from its molecular structure. The molecule is typically a white powder with a molecular weight of approximately 264.04 g/mol. Its solubility is limited in water but good in common organic solvents like ethyl acetate, dichloromethane, and chloroform, which is typical for halogenated organic compounds. The presence of the iodine atom makes it particularly reactive in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira), allowing for the formation of new carbon-carbon bonds. The fluorine atom can influence the electronic distribution, potentially activating or deactivating nearby reaction sites, and often imparts desirable properties such as metabolic stability to downstream pharmaceutical products. The ketone group itself is a site for nucleophilic attack, reductions, and condensation reactions.

Importance as a Pharmaceutical Intermediate

The primary significance of 5'-Fluoro-2'-iodoacetophenone lies in its role as a precursor for Active Pharmaceutical Ingredients (APIs), most notably lorlatinib, a critical drug in oncology. The precision required in pharmaceutical synthesis means that sourcing high-purity 5'-Fluoro-2'-iodoacetophenone (≥98%) is essential. When you need to buy this intermediate, partnering with a reputable manufacturer ensures you receive a product that meets these demanding specifications, enabling successful API synthesis and ensuring patient safety.

Supplier Reliability and Product Availability

For researchers and manufacturers, securing a dependable supply of essential intermediates is crucial. We are committed to providing high-quality 5'-Fluoro-2'-iodoacetophenone. If you are looking to purchase this compound or require detailed technical information, please contact us. We are your trusted source for reliable chemical intermediates, supporting your innovation and production needs.