In the demanding field of pharmaceutical research and development, securing high-quality intermediates is paramount. One such critical compound is 5'-Fluoro-2'-iodoacetophenone, identified by CAS number 914225-70-0. This molecule serves as a vital building block, particularly in the synthesis of advanced anticancer agents like lorlatinib. For procurement managers and R&D scientists, understanding its properties and sourcing strategies is key to maintaining project timelines and product integrity.

What is 5'-Fluoro-2'-iodoacetophenone?

5'-Fluoro-2'-iodoacetophenone is a halogenated aromatic ketone. Its chemical structure, featuring both a fluorine atom and an iodine atom on the phenyl ring adjacent to an acetyl group, imbues it with unique reactivity. This dual halogenation is instrumental in its role as a pharmaceutical intermediate. The fluorine atom can enhance metabolic stability and binding affinity in the final drug product, while the iodine atom serves as a versatile handle for various coupling reactions, crucial for constructing complex molecular architectures. We are a dedicated manufacturer committed to producing this intermediate at high purity levels, typically above 98%.

Key Applications in Pharmaceutical Synthesis

The primary application of 5'-Fluoro-2'-iodoacetophenone lies in its use as a synthesis intermediate for Active Pharmaceutical Ingredients (APIs). Its most notable role is in the synthesis pathway of lorlatinib, a potent next-generation inhibitor of anaplastic lymphoma kinase (ALK) and ROS1, widely used in the treatment of certain types of non-small cell lung cancer. The precision required in these syntheses means that the purity and consistency of intermediates like 5'-Fluoro-2'-iodoacetophenone are non-negotiable. Sourcing this chemical from a reliable manufacturer ensures that your synthesis runs smoothly and yields are optimized.

Why Source from a Reputable Manufacturer?

When you need to buy 5'-Fluoro-2'-iodoacetophenone, partnering with a trusted manufacturer offers significant advantages. As a direct supplier in China, we understand the critical need for consistent quality. Our manufacturing processes are optimized to deliver a product that meets stringent specifications, minimizing batch-to-batch variability. This reliability is essential for clients looking to purchase in bulk or for long-term supply contracts. We provide comprehensive documentation, including Certificates of Analysis, to support your regulatory and quality control requirements.

Navigating the Purchase Process

For procurement managers seeking to buy 5'-Fluoro-2'-iodoacetophenone, understanding the available supply chain is important. We offer competitive pricing and can cater to orders of varying scales, from R&D quantities to bulk commercial batches. Engaging with us directly as a manufacturer allows for clearer communication regarding lead times, custom specifications, and pricing negotiations. If you are looking for a dependable supplier of CAS 914225-70-0, we encourage you to request a quote and explore how our high-quality pharmaceutical intermediates can support your critical projects.

By ensuring a steady supply of high-grade 5'-Fluoro-2'-iodoacetophenone, we empower pharmaceutical companies to accelerate their drug development programs and bring life-saving therapies to market.