For chemists and material scientists, a deep understanding of chemical properties is the foundation for successful research and product development. 3-Bromo-5-fluoropicolinonitrile (CAS 950670-18-5) is a compound that warrants close examination due to its significant role, particularly within the pharmaceutical sector. This article explores the detailed scientific profile of this chemical, including its physical and chemical characteristics, and its primary applications, providing valuable information for anyone looking to buy or utilize this important intermediate.

Unpacking the Chemical and Physical Properties

3-Bromo-5-fluoropicolinonitrile, with the chemical name 3-bromo-5-fluoropyridine-2-carbonitrile, possesses a unique structure that dictates its reactivity and utility. Its molecular formula, C6H2BrFN2, and molecular weight, 200.99600, are precise identifiers for this compound. A key characteristic for procurement and handling is its appearance: typically a white to off-white crystalline powder. This physical state suggests it is a solid at room temperature, which is beneficial for storage and transport.

The physical properties provide further insights into its behavior:

  • Density: Approximately 1.8 ± 0.1 g/cm³ indicates it is a relatively dense solid.
  • Boiling Point: At 760 mmHg, its boiling point is 274.8 ± 40.0 °C. This high boiling point suggests thermal stability under normal processing conditions.
  • Flash Point: 120.0 ± 27.3 °C is a crucial safety parameter, indicating the temperature at which it can ignite in the presence of an ignition source. This information is vital for safe handling and storage protocols.
  • Index of Refraction: 1.581 is a property often used for characterization and quality control.

Furthermore, the specified purity of ≥98.0% underscores its suitability for applications where high precision is required. Recommended storage is in a tightly closed container in a cool, dry environment, ensuring its stability and preventing degradation.

Core Application: Pharmaceutical Intermediates

The primary utility of 3-Bromo-5-fluoropicolinonitrile is as a vital intermediate in the synthesis of pharmaceuticals. Its pyridine scaffold, adorned with bromine and fluorine atoms, along with a nitrile group, provides a versatile platform for a myriad of organic transformations. This compound is instrumental in building complex molecular structures that form the basis of various drugs. For R&D scientists and manufacturers, this means it's a key starting material for drug discovery and development pipelines, enabling the creation of novel therapeutic agents. When looking to buy this chemical, understanding its role as a precursor to potentially life-saving medications highlights its importance in the global pharmaceutical supply chain. Manufacturers and suppliers who offer this product are integral to the advancement of medicinal chemistry.

Procurement Considerations

For professionals looking to procure 3-bromo-5-fluoropicolinonitrile, the emphasis should always be on purity and reliable supply. Engaging with experienced chemical manufacturers, especially those with a strong presence in China, can provide access to competitive pricing and consistent product quality. Requesting a quote for this compound, often listed under its CAS number 950670-18-5, is the first step towards securing this essential pharmaceutical intermediate for your research or production needs.