For procurement professionals in the pharmaceutical and fine chemical industries, sourcing high-quality raw materials is paramount. One such critical intermediate is 3,4-Dihydroxy-5-Nitrobenzaldehyde, identified by its CAS number 116313-85-0. Understanding where and how to purchase this compound efficiently can significantly impact production timelines and cost-effectiveness. This article aims to guide you through the process of sourcing this essential chemical, focusing on finding reliable manufacturers and suppliers.

Understanding 3,4-Dihydroxy-5-Nitrobenzaldehyde

3,4-Dihydroxy-5-Nitrobenzaldehyde is a vital organic compound, primarily used as an intermediate in the synthesis of various pharmaceutical products, most notably Entacapone. Its chemical structure, featuring hydroxyl and nitro groups on a benzaldehyde core, makes it a versatile building block in complex organic synthesis. Typically appearing as a white to yellow crystalline powder, its purity is a key consideration for its end-use applications. Ensuring a supply with a high assay, often exceeding 99%, is crucial for pharmaceutical manufacturing to meet stringent quality standards.

Key Considerations for Procurement

When looking to buy 3,4-Dihydroxy-5-Nitrobenzaldehyde, several factors should be at the forefront of your mind:

  • Purity and Quality: As mentioned, purity is non-negotiable for pharmaceutical intermediates. Always request Certificates of Analysis (CoA) and Material Safety Data Sheets (MSDS) from potential suppliers to verify specifications.
  • Manufacturer Reliability: Partnering with a reputable manufacturer ensures consistent quality and stable supply. Look for suppliers with established production capabilities and quality control systems, such as ISO certifications.
  • Supply Chain Stability: A consistent supply is essential for uninterrupted production. Investigate the manufacturer's production capacity and inventory management practices.
  • Pricing and Commercial Terms: Obtain quotes from multiple suppliers to compare pricing. Consider not only the per-kilogram price but also bulk discounts and payment terms. Negotiation is often a key part of securing favorable commercial arrangements.
  • Regulatory Compliance: Ensure the supplier can provide necessary documentation and adhere to relevant chemical regulations in your region.

Finding Manufacturers and Suppliers in China

China is a major hub for chemical manufacturing, offering a vast network of producers for intermediates like 3,4-Dihydroxy-5-Nitrobenzaldehyde. To find trustworthy suppliers, consider these approaches:

  • B2B Platforms: Websites like Made-in-China.com, Alibaba.com, and GlobalSources.com list numerous chemical manufacturers and suppliers. Use specific search terms such as '3,4-Dihydroxy-5-Nitrobenzaldehyde manufacturer China' or 'CAS 116313-85-0 supplier' to narrow down your search.
  • Industry Directories and Trade Shows: Chemical industry directories and participation in international trade shows (e.g., CPHI) can provide direct access to manufacturers and opportunities for building relationships.
  • Direct Inquiries: Once you identify potential suppliers, initiate direct contact. Prepare a detailed inquiry that includes your required quantity, purity specifications, desired delivery timeline, and any specific regulatory documentation needed.

The Importance of Entacapone Synthesis

The significant demand for 3,4-Dihydroxy-5-Nitrobenzaldehyde is largely driven by its role as an intermediate in the synthesis of Entacapone, a medication used to treat Parkinson's disease. Entacapone works by inhibiting catechol-O-methyltransferase (COMT), an enzyme that breaks down levodopa, thereby prolonging its therapeutic effect. The purity and consistent availability of 3,4-Dihydroxy-5-Nitrobenzaldehyde directly influence the quality and efficacy of the final Entacapone API.

Making the Purchase Decision

When evaluating potential suppliers for 3,4-Dihydroxy-5-Nitrobenzaldehyde, look for companies that can provide:

  • High purity material (≥99%).
  • Comprehensive technical documentation (CoA, MSDS, etc.).
  • Competitive pricing, especially for bulk orders.
  • Reliable and timely delivery.
  • Excellent customer service and responsiveness to inquiries.

By focusing on these aspects and conducting thorough due diligence, procurement managers can secure a dependable supply of 3,4-Dihydroxy-5-Nitrobenzaldehyde, ensuring the smooth operation of their pharmaceutical manufacturing processes. As a leading supplier, we are committed to meeting these demands and facilitating your success in sourcing this critical chemical intermediate.