In the dynamic field of pharmaceutical development, the precise formulation of active pharmaceutical ingredients (APIs) is paramount. Among the advanced excipients revolutionizing drug delivery, specialized lipids play a pivotal role, particularly in the creation of sophisticated systems like Lipid Nanoparticles (LNPs). This guide focuses on the utility and sourcing of 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(succinyl) (sodium salt), a key functionalized phospholipid, for researchers and procurement managers seeking to buy high-quality components.

Understanding Succinyl PE: A Functionalized Lipid for Innovation

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-N-(succinyl) (sodium salt), identified by its CAS number 111613-33-3, is a vital headgroup-modified lipid. Its unique structure, featuring two oleic acid tails and a succinyl-functionalized phosphoethanolamine headgroup, makes it exceptionally useful for creating stable and effective drug delivery vehicles. The succinyl group introduces a negative charge and can influence the overall behavior and targeting capabilities of lipid-based formulations. Its appearance as a white to light yellow waxy solid is typical for many high-purity lipids, and its purity, often exceeding 97.0%, is a critical factor for demanding pharmaceutical applications.

The Crucial Role in Lipid Nanoparticle (LNP) Formulation

LNPs have gained significant attention for their ability to encapsulate and deliver sensitive payloads, such as mRNA and small interfering RNA (siRNA), to target cells. Succinyl PE, as a component in LNP formulations, contributes to the overall stability and physicochemical properties of the nanoparticles. It can influence particle size, charge distribution, and the release kinetics of the encapsulated drug. For scientists working on next-generation therapeutics, understanding how to incorporate and optimize the use of lipids like succinyl PE is essential. Procurement managers often look for suppliers who can provide detailed technical data and consistent quality for these critical raw materials. If you are looking to buy this essential lipid, ensure your supplier can meet stringent quality standards.

Sourcing High-Purity Lipids: Partnering with a Reliable Manufacturer

The efficacy and safety of advanced drug delivery systems are directly tied to the quality of the raw materials used. Therefore, selecting a reputable manufacturer and supplier for lipids like 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(succinyl) is a strategic decision. A trusted supplier will not only offer competitive pricing but also guarantee high purity levels, robust quality control, and reliable supply chain management. When you need to purchase succinyl PE for your research or production, consider manufacturers with a strong track record in producing specialized lipids for the pharmaceutical industry. Many leading suppliers are based in regions known for chemical synthesis innovation, such as China, offering excellent value and expertise.

Key Considerations for Procurement Managers

For procurement professionals, sourcing critical lipids involves evaluating several factors: purity, lot-to-lot consistency, scalability of production, and overall cost-effectiveness. Engaging with a manufacturer that offers comprehensive support, including Certificates of Analysis (CoA) and technical documentation, is crucial. Furthermore, inquiring about bulk purchase options and requesting samples for validation can streamline the procurement process. By partnering with an established supplier, you can ensure a stable supply of high-purity 111613-33-3, thereby de-risking your product development pipeline and accelerating your path to market. If you're seeking to buy this specialized lipid, don't hesitate to contact us for a quote and detailed product information.

Conclusion

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-N-(succinyl) (sodium salt) represents a significant advancement in lipid excipients, enabling groundbreaking developments in drug delivery. For researchers and formulators, securing a consistent and high-quality supply is key to success. We are a premier manufacturer and supplier dedicated to providing the pharmaceutical industry with the essential lipids required for innovation. Contact us today to discuss your needs and to buy the quality lipids you require.