The pharmaceutical industry's increasing focus on peptide-based therapeutics has amplified the demand for high-quality, specialized chemical intermediates. These molecular building blocks form the very foundation of peptide synthesis, enabling the creation of complex molecules with therapeutic potential. Among these critical components, Fmoc-Asp(OtBu)-OH (13C4,15N), identified by its CAS number 1217468-27-3, plays a significant role, particularly for advanced research and quantitative applications.

Fmoc-Asp(OtBu)-OH (13C4,15N) is a derivative of the amino acid aspartic acid that has been specifically engineered with stable isotopes of carbon (13C4) and nitrogen (15N). This isotopic labeling is not merely a subtle modification; it imbues the compound with the capacity to serve as an internal standard in analytical techniques like mass spectrometry. For researchers and procurement managers within pharmaceutical and biotechnology companies, this capability is transformative for achieving precision in their work.

The primary utility of this labeled amino acid derivative is in the field of Solid-Phase Peptide Synthesis (SPPS), especially when employing the Fmoc strategy. By incorporating this isotopically distinct aspartic acid residue into a peptide sequence, scientists can accurately quantify the presence and concentration of the synthesized peptide. This is crucial for critical stages of drug development, such as pharmacokinetic studies, which evaluate how a drug is absorbed, distributed, metabolized, and excreted by the body. For those looking to buy these essential intermediates, understanding the benefits of isotopic labeling is key.

Reliable sourcing of such specialized chemical intermediates is vital. Manufacturers in China are prominent suppliers of high-purity chemical compounds, including isotopically labeled amino acids. By purchasing Fmoc-Asp(OtBu)-OH (13C4,15N) from a reputable supplier, organizations can ensure the required isotopic enrichment and chemical purity, thereby guaranteeing the accuracy and validity of their research data. Competitive pricing and dependable supply chains from these manufacturers further support the advancement of drug discovery programs.

Furthermore, the application of Fmoc-Asp(OtBu)-OH (13C4,15N) extends to metabolic tracing. The stable isotopes allow researchers to track the journey of the labeled amino acid through biological systems, providing deep insights into protein synthesis, metabolism, and degradation processes. This information is invaluable for understanding the biological behavior of peptide-based drugs and for optimizing their therapeutic efficacy.

In conclusion, Fmoc-Asp(OtBu)-OH (13C4,15N) exemplifies the critical importance of specialized chemical intermediates in advancing peptide-based drug development. Its unique isotopic labeling provides essential capabilities for quantitative analysis and metabolic studies. For any organization involved in the complex process of bringing new peptide therapeutics to market, securing a high-quality supply of such vital building blocks from trusted chemical manufacturers is a strategic imperative.