The landscape of drug discovery is continuously evolving, with peptide-based therapeutics gaining increasing prominence due to their specificity and biological activity. At the heart of developing these advanced molecules lies sophisticated chemical synthesis, where specialized building blocks play a pivotal role. Among these, Fmoc-Asp(OtBu)-OH (13C4,15N), identified by CAS number 1217468-27-3, is a particularly vital reagent, empowering researchers to achieve unprecedented levels of accuracy and insight.

Fmoc-Asp(OtBu)-OH (13C4,15N) is a derivative of aspartic acid that has been meticulously labeled with stable isotopes of carbon (13C4) and nitrogen (15N). This isotopic enrichment is not merely a technical detail; it directly translates into enhanced analytical capabilities, particularly when utilizing techniques like quantitative mass spectrometry. For scientists and procurement managers in the pharmaceutical industry, understanding the value proposition of such specialized chemical intermediates is key to optimizing research and development pipelines.

The primary utility of this compound in drug discovery stems from its application in peptide synthesis. As a standard building block in Fmoc Solid-Phase Peptide Synthesis (SPPS), it allows for the seamless incorporation of a labeled aspartic acid residue into a peptide sequence. When the synthesized peptide is analyzed, the isotopic label serves as an internal standard, enabling highly precise quantification. This is critically important for pharmacokinetic (PK) and pharmacodynamic (PD) studies, where accurate measurement of drug levels in biological samples is essential for determining dosage, efficacy, and safety profiles. Pharmaceutical companies looking to buy these advanced reagents can find reliable suppliers in China offering competitive pricing.

Furthermore, the labeled nature of Fmoc-Asp(OtBu)-OH (13C4,15N) facilitates intricate metabolic tracing studies. Researchers can follow the pathway of the labeled aspartic acid as it is incorporated into peptides and subsequently metabolized within biological systems. This provides invaluable data on peptide stability, degradation pathways, and the overall fate of the drug candidate within the body. Such insights are fundamental for understanding drug action and improving therapeutic outcomes.

The demand for high-quality, precisely labeled compounds like Fmoc-Asp(OtBu)-OH (13C4,15N) is met by specialized chemical manufacturers who adhere to stringent quality control standards. These manufacturers ensure that the isotopic enrichment and overall purity meet the demanding requirements of pharmaceutical research. When you choose to purchase this product, you are investing in the robustness and reliability of your analytical data.

In summary, Fmoc-Asp(OtBu)-OH (13C4,15N) is an indispensable tool for modern drug discovery, offering enhanced precision in peptide synthesis and quantitative analysis. Its application in PK/PD studies and metabolic tracing significantly accelerates the development of novel peptide-based therapeutics. For organizations aiming to push the boundaries of pharmaceutical innovation, securing a consistent and high-quality supply of this critical intermediate from a trusted manufacturer is a strategic necessity.