For professionals in the pharmaceutical and fine chemical industries, a thorough understanding of key chemical intermediates is vital for effective research, development, and manufacturing. 1-(2-Ethoxy-ethyl)-2-piperidin-4-yl-1H-benzimidazole, identified by CAS number 110963-63-8, stands out as a crucial molecule primarily due to its role as an intermediate in the synthesis of the antihistamine drug, Bilastine. This article delves into its chemical profile, properties, and significance for those looking to buy or source this compound.

Chemical Identity and Nomenclature: The compound's systematic name, 1-(2-Ethoxy-ethyl)-2-piperidin-4-yl-1H-benzimidazole, precisely describes its molecular structure. It is known by various synonyms, including Bilastine Intermediate 1, Bilasten intermediate 2, and 1-(2-ethoxyethyl)-2-(4-piperidinyl)-1H-benzimidazole. These names highlight its direct connection to the production of Bilastine. The CAS number 110963-63-8 serves as a unique identifier for this specific chemical entity in databases and trade.

Physicochemical Properties: Characteristically, 1-(2-Ethoxy-ethyl)-2-piperidin-4-yl-1H-benzimidazole presents as a white to off-white crystalline powder. Its molecular formula is C16H23N3O, with a molecular weight of approximately 273.37 g/mol. Key properties reported include a density of around 1.18 g/cm³ and a predicted boiling point of 452.2 °C at 760 mmHg. It is generally stable at room temperature and exhibits solubility in common organic solvents, making it compatible with standard laboratory and industrial synthesis procedures. Its pKa is predicted to be around 10.02.

Significance in Pharmaceutical Synthesis: The paramount importance of this intermediate lies in its application as a building block for Bilastine. Bilastine is a non-sedating, long-acting H1 antihistamine that has gained widespread use in treating allergic conditions such as allergic rhinitis and chronic urticaria. The demand for effective allergy medications ensures a consistent market need for high-quality Bilastine intermediates. Pharmaceutical manufacturers depend on reliable suppliers who can consistently deliver this compound at the required purity levels (typically ≥98%) to ensure the efficacy and safety of the final drug product.

For companies looking to procure 1-(2-Ethoxy-ethyl)-2-piperidin-4-yl-1H-benzimidazole, understanding its chemical profile is the first step toward making informed purchasing decisions. Engaging with experienced manufacturers and suppliers, particularly those with strong expertise in pharmaceutical intermediates, is crucial for ensuring quality, competitive pricing, and a secure supply chain.