For chemists and formulators in the pharmaceutical industry, understanding the synthesis and application of key intermediates is fundamental to efficient drug development and production. 1-(2-Ethoxy-ethyl)-2-piperidin-4-yl-1H-benzimidazole, identified by its CAS number 110963-63-8, is one such critical compound, widely recognized for its role as a precursor in the manufacturing of Bilastine. This article explores its chemical properties, common synthesis routes, and its significance in pharmaceutical applications, providing insights for those looking to buy this intermediate.

Chemical Properties and Characteristics: 1-(2-Ethoxy-ethyl)-2-piperidin-4-yl-1H-benzimidazole is typically presented as a white to off-white powder. It exhibits good stability at room temperature and is soluble in many organic solvents, which are favorable attributes for its use in various synthetic processes. With a molecular formula of C16H23N3O and a molecular weight of approximately 273.37 g/mol, its structure incorporates a benzimidazole ring, a piperidine moiety, and an ethoxyethyl side chain, contributing to its specific reactivity and utility.

Synthesis Pathways: While specific proprietary synthesis routes may vary among manufacturers, a general understanding of its preparation involves multi-step organic synthesis. A common conceptual approach might involve reactions that build the benzimidazole ring and then functionalize it with the piperidine and ethoxyethyl components. This often requires careful control of reaction conditions, reagent selection, and purification techniques to achieve the desired high purity (typically ≥98%). For companies looking to purchase this chemical, inquiring about the synthesis route and associated quality control measures can be beneficial.

Applications in Pharmaceutical Manufacturing: The primary and most significant application of 1-(2-Ethoxy-ethyl)-2-piperidin-4-yl-1H-benzimidazole is its role as a key intermediate in the synthesis of Bilastine. Bilastine is a second-generation H1 antihistamine used for the symptomatic treatment of allergic rhinitis and chronic idiopathic urticaria. The efficiency and purity of the synthesis of this intermediate directly influence the yield, purity, and overall cost of the final Bilastine API. Therefore, reliable sourcing from manufacturers who specialize in producing high-purity pharmaceutical intermediates is essential.

For pharmaceutical companies, securing a consistent supply of this intermediate is crucial for their production pipelines. Whether for ongoing manufacturing or for new drug development projects, identifying trusted suppliers who can guarantee quality and provide competitive pricing when you buy is a strategic imperative. Exploring manufacturers based in China, known for their robust chemical synthesis capabilities, is often a viable option for obtaining this vital pharmaceutical intermediate.