For research and development chemists, understanding the precise chemical properties and safe handling procedures for intermediates like 2-Cyano-Phenothiazine (CAS 38642-74-9) is fundamental to successful synthesis and experimentation. This article provides essential insights into its characteristics and best practices for laboratory use.

Chemical Structure and Physical Properties
2-Cyano-Phenothiazine is an organic compound with the molecular formula C13H8N2S and a molecular weight of approximately 224.28 g/mol. Its structure features a tricyclic phenothiazine core, known for its electron-donating properties, with a nitrile (-CN) group attached at the 2-position. This nitrile group is a versatile functional handle that can participate in various organic transformations.

Physically, it typically presents as a yellow to yellow-green crystalline powder. The melting point is a key identifier and quality parameter, generally falling within the range of 202-203.5°C. This high melting point indicates a stable solid form under ambient conditions. While specific solubility data might vary, similar compounds often show solubility in organic solvents like chloroform or DMSO, with limited solubility in water.

Key Specifications and Purity
When sourcing 2-Cyano-Phenothiazine for R&D purposes, purity is paramount. Manufacturers commonly offer this intermediate with an assay of 98.5% or higher. High-purity grades, such as those around 99.7%, are often preferred for sensitive synthetic routes where trace impurities could lead to unwanted side reactions or affect the yield and purity of the final product. Research chemists should always consult the supplier's Certificate of Analysis (CoA) to verify these specifications.

Handling and Safety Precautions
As with any chemical intermediate, appropriate safety precautions must be observed when handling 2-Cyano-Phenothiazine:

  • Personal Protective Equipment (PPE): Always wear appropriate PPE, including safety goggles, chemical-resistant gloves (e.g., nitrile), and a lab coat.
  • Ventilation: Handle the powder in a well-ventilated area or a fume hood to minimize inhalation of dust particles.
  • Storage: Store 2-Cyano-Phenothiazine in a cool, dry place, away from direct sunlight and incompatible materials. Keep the container tightly closed to prevent moisture absorption and degradation. Based on some supplier recommendations, storage at 2-8°C in a dark place might be optimal for long-term stability.
  • Incompatibilities: While specific incompatibilities should be checked with the Safety Data Sheet (SDS), phenothiazine derivatives can sometimes react with strong oxidizing agents.
  • Hazard Statements: Be aware of potential hazards. Based on similar compounds, warnings like H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation) might apply. Always consult the SDS for definitive information.

Applications in Research and Synthesis
Beyond its established role as an intermediate for pericyazine, 2-Cyano-Phenothiazine serves as a valuable building block for organic chemists exploring new synthetic pathways. The nitrile group can be hydrolyzed to a carboxylic acid, reduced to an amine, or undergo various addition reactions. Its phenothiazine core offers possibilities for developing novel compounds with potential pharmacological activities or in materials science applications.

For research chemists seeking a reliable source for this compound, partnering with chemical suppliers that emphasize quality and provide comprehensive technical documentation is essential. Understanding the chemical properties and adhering to safety protocols will ensure the successful and safe utilization of 2-Cyano-Phenothiazine in your laboratory endeavors.