The intricate world of pharmaceutical research and development relies heavily on a steady supply of specialized chemical intermediates. Among these, heterocyclic compounds play a pivotal role due to their diverse structures and potential biological activities. One such compound that has garnered attention is 7,10-Dichloro-2-methoxybenzo[b]-1,5-naphthyridine, identified by its CAS number 6626-40-0.

Understanding the Compound's Significance

7,10-Dichloro-2-methoxybenzo[b]-1,5-naphthyridine is a nitrogen-containing heterocyclic molecule. Its chemical formula is C13H8Cl2N2O, with a molecular weight of 279.12. This compound is particularly significant as an intermediate in the synthesis of Pyronaridine, a promising antimalarial agent. The presence of chlorine atoms and a methoxy group within its naphthyridine core contributes to its unique chemical properties, influencing its reactivity and suitability for various synthetic pathways.

Applications in Drug Discovery and Synthesis

The primary application of 7,10-Dichloro-2-methoxybenzo[b]-1,5-naphthyridine lies in its role as a precursor in the pharmaceutical industry. Specifically, its use in the synthesis of Pyronaridine underscores its importance in the development of treatments for infectious diseases. Beyond this established use, its complex heterocyclic structure makes it a valuable building block for medicinal chemists exploring novel drug candidates. Researchers may investigate its derivatives for potential activities in areas such as oncology, antiviral therapies, or other therapeutic fields.

Sourcing and Quality Assurance

For scientists and researchers engaged in drug discovery, obtaining high-quality 7,10-Dichloro-2-methoxybenzo[b]-1,5-naphthyridine is paramount. Reputable chemical suppliers and manufacturers provide this compound with guaranteed purity levels, often exceeding 95% as determined by HPLC. Key specifications to look for include:

  • Purity: Essential for predictable reaction outcomes and to avoid complications in downstream synthesis.
  • Appearance: Typically a pale yellow solid.
  • Storage: Proper storage conditions (e.g., under inert gas, refrigerated) are crucial for maintaining its chemical stability and efficacy.
  • Supporting Documentation: Certificates of Analysis (CoA) and Safety Data Sheets (SDS) are vital for research integrity and safety compliance.

When looking to buy this intermediate, consider established manufacturers and suppliers who can offer reliable availability and competitive pricing, especially for larger R&D quantities. Enquiring about pricing and lead times is a standard part of the procurement process for any research chemical.

Conclusion

7,10-Dichloro-2-methoxybenzo[b]-1,5-naphthyridine (CAS 6626-40-0) stands as a testament to the importance of specialized intermediates in modern pharmaceutical R&D. Its role in the synthesis of vital medications like Pyronaridine, combined with its potential as a versatile building block for new drug discovery, makes it a compound of significant interest. Researchers and procurement professionals seeking this material should always prioritize purity, reliable sourcing, and thorough documentation from trusted chemical suppliers.