For chemists and material scientists, understanding the detailed properties and synthesis of chemical intermediates is fundamental to successful application. 2-Amino-4,5-dimethoxybenzoic acid, identified by its CAS number 5653-40-7, is a compound that warrants close examination due to its utility across various industries. This article provides an in-depth look at its chemical characteristics and common synthesis pathways, highlighting its importance as a fine chemical intermediate.

Chemical Profile of 2-Amino-4,5-dimethoxybenzoic Acid

2-Amino-4,5-dimethoxybenzoic acid typically presents as a brown solid. Key chemical properties include:

  • Molecular Formula: C9H11NO4
  • Molecular Weight: 197.19 g/mol
  • Purity: Commonly available at ≥98.0% or 99% purity.
  • Appearance: Brown Solid
  • Solubility: Soluble in methanol and water, slightly soluble in acetonitrile and DMSO.
  • Melting Point: Approximately 169-173 °C (with decomposition).
  • Stability: May be sensitive to air oxidation and light.

Its structure features an amino group and a carboxylic acid group on a dimethoxy-substituted benzene ring, making it a versatile molecule for various chemical transformations.

Synthesis and Manufacturing Methods

Several methods exist for the synthesis of 2-Amino-4,5-dimethoxybenzoic acid. A common approach involves the reduction of a nitro precursor. For instance, methyl-4,5-dimethoxy-2-nitrobenzoate can be hydrolyzed and then catalytically hydrogenated using a Palladium on Carbon (Pd/C) catalyst. Another route may involve starting with 4,5-dimethoxy-2-nitrobenzoic acid and reducing the nitro group, often using methods like catalytic hydrogenation with Pd/C or chemical reduction with agents like iron powder in acidic media. Manufacturers often optimize these processes to achieve high yields and purity, ensuring that the product meets stringent specifications for pharmaceutical and fine chemical applications.

Safety and Handling Considerations

While an invaluable intermediate, 2-Amino-4,5-dimethoxybenzoic acid requires careful handling. It is classified as an irritant (Xi) with hazard statements including H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Standard laboratory safety precautions, such as wearing protective gloves, eye protection, and working in a well-ventilated area or fume hood, are recommended. Proper storage, away from light and moisture, is also important to maintain its stability.

Procurement for Industrial Use

For businesses seeking to buy 2-Amino-4,5-dimethoxybenzoic acid, sourcing from reputable manufacturers and suppliers in China is a strategic choice. These suppliers can offer competitive pricing and ensure consistent quality, often exceeding 99% purity. Companies like NINGBO INNO PHARMCHEM CO.,LTD. specialize in providing these critical intermediates, offering detailed technical data and reliable supply chains. Requesting a quote and comparing specifications will help you secure the best material for your synthesis needs.

NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing high-quality 2-Amino-4,5-dimethoxybenzoic acid, backed by expertise in chemical synthesis and manufacturing. We are a trusted supplier ready to meet your demands. Contact us to learn more about our products and how we can support your research and industrial applications.