In the dynamic field of chemical synthesis, identifying and reliably sourcing key intermediates is fundamental for innovation and production. 2-Hydroxy-3-trifluoromethylpyridine, identified by its CAS number 22245-83-6, is a prime example of such a critical compound, widely utilized for its unique properties in pharmaceutical and agrochemical research and manufacturing.

Understanding the Compound’s Structure and Properties

2-Hydroxy-3-trifluoromethylpyridine is a heterocycle featuring a pyridine ring functionalized with both a hydroxyl (-OH) group and a trifluoromethyl (-CF3) group. This combination imparts specific characteristics: the hydroxyl group can act as a reactive site for various transformations, while the strongly electron-withdrawing trifluoromethyl group significantly influences the molecule's electronic properties, lipophilicity, and metabolic stability. Typically supplied as an off-white crystalline powder, it exhibits a melting point between 150-153°C, indicative of its solid state under standard conditions. With a purity often exceeding 98.0%, it serves as a dependable building block.

Key Applications Driving Demand

The primary value of 2-Hydroxy-3-trifluoromethylpyridine lies in its role as an intermediate:

  • Pharmaceutical Industry: It is extensively used in the synthesis of Active Pharmaceutical Ingredients (APIs). The trifluoromethyl moiety is known to enhance a drug’s efficacy, bioavailability, and resistance to enzymatic degradation, making this intermediate invaluable for drug discovery programs targeting various therapeutic areas.
  • Agrochemical Sector: In the development of new crop protection agents, this compound helps in formulating pesticides and herbicides that offer improved potency, stability, and target specificity.
  • Organic Synthesis: Beyond these sectors, it is a versatile reactant for creating complex organic molecules, facilitating diverse research projects and the production of fine chemicals.

Sourcing Strategies: Ensuring Quality and Availability

For scientists and procurement managers needing to buy 2-Hydroxy-3-trifluoromethylpyridine, establishing a reliable supply chain is crucial. Manufacturers and suppliers play a vital role here. Sourcing from reputable companies, particularly those with significant manufacturing capabilities in regions like China, often provides access to:

  • High-Purity Products: Look for suppliers that guarantee assay purity of u226598.0%.
  • Competitive Pricing: Obtain quotes from multiple sources to ensure cost-effectiveness for your projects.
  • Consistent Supply: Partner with suppliers who can maintain steady inventory and timely delivery for both research and production scales.
  • Technical Support: Access to MSDS and expert advice is important for safe and efficient use.

By selecting a trustworthy 2-Hydroxy-3-trifluoromethylpyridine supplier, you ensure that your synthesis projects are built on a foundation of quality and reliability.

In conclusion, the strategic importance of 2-Hydroxy-3-trifluoromethylpyridine in modern chemical synthesis cannot be overstated. Its unique structural features make it an indispensable intermediate, and a focus on sourcing from reputable manufacturers ensures the success of vital research and production efforts.