For chemists and researchers engaged in organic synthesis, understanding the synthesis and reactivity of key intermediates like 2-Phenoxyethyl Chloride (CAS: 622-86-6) is fundamental to successful project outcomes. This compound, with its distinct chemical structure, serves as a valuable tool in the creation of diverse chemical products, particularly in the pharmaceutical and fine chemical industries.

Synthesis Pathways for 2-Phenoxyethyl Chloride

2-Phenoxyethyl Chloride, represented by the molecular formula C8H9ClO and a molecular weight of 156.61 g/mol, is primarily synthesized through established organic reactions. A common method involves the Williamson ether synthesis, where phenol or a phenoxide salt is reacted with 1,2-dichloroethane under basic conditions. Alternatively, it can be prepared by the direct chlorination of 2-phenoxyethanol. These methods allow for the production of the compound with good yields and high purity, typically exceeding 98.0%, which is essential for its downstream applications.

Reactivity and Applications in Synthesis

The reactivity of 2-Phenoxyethyl Chloride is largely dictated by its chloroalkyl group, which is an excellent leaving group in nucleophilic substitution reactions. This allows for the facile introduction of the phenoxyethyl moiety into a wide range of organic molecules. For instance, it is widely used as an intermediate in the synthesis of pharmaceutical compounds, including those used as antidepressants and in oncology treatments. The ability to precisely control the reaction and ensure high purity is why many seek to buy 2-Phenoxyethyl Chloride.

Furthermore, its participation in various coupling reactions, such as palladium-catalyzed cross-couplings, expands its utility in complex organic synthesis. Researchers in academic and industrial settings rely on its consistent reactivity to build intricate molecular architectures for new materials, agrochemicals, and drug candidates. This makes finding a reliable 2-Phenoxyethyl Chloride supplier a key consideration for many R&D projects.

Sourcing and Quality Assurance

When you need to purchase 2-Phenoxyethyl Chloride, it is crucial to source it from reputable manufacturers. A high-purity product (≥98.0%) with minimal impurities ensures predictable reaction outcomes and compliance with industry standards. Many find that partnering with a dedicated manufacturer in China offers competitive 2-Phenoxyethyl Chloride price points and reliable access to quantities required for both research and commercial production. Always verify product specifications through a Certificate of Analysis (CoA) provided by the supplier.

The chemical synthesis and reactivity of 2-Phenoxyethyl Chloride underscore its importance as a foundational intermediate in modern chemistry. Its availability from dependable sources empowers chemists to drive innovation and create valuable products across diverse industries.