In the dynamic field of organic synthesis, the availability of versatile and reactive chemical building blocks is crucial for innovation. 2-Phenoxyethyl Chloride (CAS: 622-86-6) stands out as a compound with significant utility, owing to its unique molecular structure and reactivity. For synthetic chemists and researchers, understanding its properties and how to effectively buy 2-Phenoxyethyl Chloride is key to advancing their projects.

Chemical Profile of 2-Phenoxyethyl Chloride

2-Phenoxyethyl Chloride, with the chemical formula C8H9ClO and a molecular weight of 156.61 g/mol, is characterized by a phenoxy group attached to a chloroethyl chain. This structure imparts a dual functionality, allowing it to participate in a wide array of chemical transformations. It typically appears as a white to off-white solid, with a melting point of 28°C and a boiling point around 219°C. Its stability under standard laboratory conditions makes it a reliable reagent for complex synthetic routes.

Synthetic Versatility and Applications

The reactivity of 2-Phenoxyethyl Chloride makes it an indispensable reagent in organic synthesis. Its chloroalkyl group is susceptible to nucleophilic substitution, enabling the introduction of the phenoxyethyl moiety into various substrates. This capability is particularly valuable when synthesizing pharmaceuticals, such as certain antidepressant and anti-cancer agents, where the precise incorporation of specific functional groups is critical. For instance, its use in the synthesis of nafazodone and tamoxifen derivatives highlights its importance.

Beyond pharmaceutical applications, 2-Phenoxyethyl Chloride is employed in the creation of fine chemicals and advanced materials. Its participation in multicomponent coupling reactions and its role as a precursor in various chemical processes underscore its versatility. Researchers often seek to purchase 2-Phenoxyethyl Chloride to explore new reaction mechanisms or to synthesize novel compounds with desired properties.

Sourcing Strategy for Researchers and Manufacturers

When you need to buy 2-Phenoxyethyl Chloride for your laboratory or manufacturing needs, opting for a trusted 2-Phenoxyethyl Chloride supplier is essential. Factors such as purity (typically guaranteed at ≥98.0%), consistent quality, and competitive pricing are primary considerations. Sourcing from a reputable manufacturer in China can often provide the best balance of cost-effectiveness and product quality.

For R&D purposes, smaller quantities are often sufficient, while larger-scale production demands bulk purchasing. A good supplier will cater to both needs, offering flexible packaging and delivery options. Always request a Certificate of Analysis (CoA) to verify the specifications and ensure the material is suitable for your intended reactions.

The compound's established role in synthetic chemistry, coupled with its availability from reliable sources, makes 2-Phenoxyethyl Chloride a cornerstone for many organic synthesis projects. Whether you are developing new APIs or exploring novel chemical pathways, securing a consistent supply of this key intermediate is fundamental to your success.