In the realm of fine chemical intermediates, boronic acids play a crucial role, facilitating complex molecular transformations that are vital for numerous industries. 4-Butylphenylboronic Acid (CAS: 145240-28-4) is a prime example, celebrated for its contribution to advanced organic synthesis, particularly through its participation in the widely applied Suzuki-Miyaura cross-coupling reaction. As a key reagent for chemists and manufacturers, understanding its synthesis and application benefits is essential.

Synthesis and Properties of 4-Butylphenylboronic Acid

4-Butylphenylboronic Acid is an aromatic boronic acid characterized by a butyl substituent on the phenyl ring. This substituent enhances its solubility in organic media, a property that significantly aids in its use within various chemical processes, especially those involving non-polar or moderately polar solvents. Synthetically, organoboron compounds like this are often prepared through organometallic routes, typically involving the reaction of a Grignard reagent or an organolithium compound with a borate ester, followed by hydrolysis. The specific synthetic pathway for 4-Butylphenylboronic Acid ensures a high level of purity, commonly exceeding 98% as determined by HPLC. This level of purity is non-negotiable for applications where precise stoichiometry and minimal side reactions are critical, such as in pharmaceutical intermediate synthesis.

Catalytic Role in Suzuki-Miyaura Coupling

The primary utility of 4-Butylphenylboronic Acid lies in its function as a nucleophilic coupling partner in palladium-catalyzed Suzuki-Miyaura reactions. This reaction is a cornerstone of modern organic chemistry, enabling the efficient formation of carbon-carbon bonds between aryl or vinyl halides (or pseudohalides) and organoboron compounds. The boronic acid group (-B(OH)2) readily undergoes transmetalation with the palladium catalyst, allowing for the construction of biaryl systems, styrenes, and other complex aromatic structures. The butyl group on the phenyl ring can influence the reactivity and solubility profile of the coupling, sometimes leading to improved outcomes in specific reaction conditions.

For companies that need to buy 4-Butylphenylboronic Acid, understanding these catalytic applications is key to appreciating its value. It is a staple in research laboratories and industrial production facilities focused on:

  • Pharmaceutical Synthesis: As an intermediate for APIs and drug candidates.
  • Material Science: For creating functional polymers, liquid crystals, and electronic materials.
  • Agrochemicals: In the synthesis of active ingredients.

Reliable Supply from a Dedicated Manufacturer

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By leveraging our expertise as a supplier of fine chemical intermediates, we empower our clients to advance their research and production goals with confidence. Choosing a manufacturer that prioritizes quality and offers competitive pricing for 4-Butylphenylboronic Acid is a strategic decision that can significantly impact the efficiency and success of your synthetic endeavors.