The development of effective pharmaceuticals relies heavily on intricate chemical synthesis pathways, where each intermediate plays a specific and vital role. For widely prescribed medications like Rosuvastatin Calcium, a statin used to manage cholesterol levels, the journey from raw materials to the final API is complex. Central to this process is the intermediate [[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]methyl]triphenylphosphonium Bromide, identified by its CAS number 154057-58-6.

Understanding the Structure and Function

[[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]methyl]triphenylphosphonium Bromide is a quaternary phosphonium salt. Its molecular structure features a quinoline core substituted with a cyclopropyl group and a fluorophenyl group, linked to a triphenylphosphonium moiety via a methyl bridge. This structural design makes it a highly effective reagent in organic synthesis, particularly in reactions requiring the formation of new carbon-carbon bonds.

In the multi-step synthesis of Rosuvastatin Calcium, this specific phosphonium salt is often employed in a Wittig reaction or a related phosphonate ester (Horner-Wadsworth-Emmons) reaction. These reactions are crucial for introducing specific unsaturated side chains into the growing drug molecule. The high purity of the intermediate, typically specified as ≥98.0%, is essential to ensure the stereochemical control and regioselectivity required for producing the correct isomer of Rosuvastatin Calcium, thereby maximizing therapeutic efficacy and minimizing potential side effects.

Sourcing and Quality Control for Manufacturers

For pharmaceutical companies and contract manufacturing organizations (CMOs), sourcing this intermediate requires diligence. Buyers need to partner with reliable chemical manufacturers who can consistently supply material meeting strict pharmaceutical specifications. When considering a supplier, key attributes to look for include:

  • Manufacturing Expertise: Experience in synthesizing complex organic intermediates and managing batch-to-batch consistency.
  • Quality Management Systems: Adherence to GMP principles and robust in-house QC/QA protocols.
  • Documentation: Availability of comprehensive documentation, including Certificates of Analysis (CoA), Material Safety Data Sheets (MSDS), and potentially Drug Master Files (DMFs) or their equivalents.
  • Supply Chain Reliability: A proven track record of timely deliveries and inventory management to avoid production disruptions.

As a manufacturer of pharmaceutical intermediates, NINGBO INNO PHARMCHEM CO.,LTD. provides [[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]methyl]triphenylphosphonium Bromide with a focus on purity and consistency. We understand that our products are the foundation of critical medications. Therefore, our production processes are designed to meet the exacting demands of the pharmaceutical industry. If your research and development or manufacturing processes require this key intermediate, we invite you to contact us to discuss your needs and explore partnership opportunities. Investing in a quality supplier for CAS 154057-58-6 is an investment in the quality of your final product.