The field of organic chemistry, particularly as it pertains to pharmaceutical development, is rich with versatile molecular scaffolds. Among these, quinoline derivatives hold a significant place due to their presence in numerous biologically active compounds. This article focuses on a key quinoline intermediate: 4-oxo-1,4-dihydroquinoline-3-carboxylic acid (CAS 13721-01-2), exploring its chemical characteristics, synthesis pathways, and critical applications, especially within the pharmaceutical sector. For those looking to buy 4-oxo-1,4-dihydroquinoline-3-carboxylic acid, understanding its chemical profile is the first step.

Chemical Properties and Synthesis Overview

4-oxo-1,4-dihydroquinoline-3-carboxylic acid is characterized by its solid form, typically appearing as off-white to light yellow crystals. Its molecular formula is C10H7NO3, with a molecular weight of 189.17 g/mol. Key physical properties include a high melting point, around 269-270℃, indicating significant thermal stability. The synthesis of this compound often involves the alkaline hydrolysis of corresponding esters, such as ethyl 4-hydroxyquinoline-3-carboxylate. This process, when carried out under controlled conditions with reagents like sodium hydroxide followed by acidification, yields the desired product with high purity and good yield, making it an accessible intermediate for chemical manufacturers.

Applications in Pharmaceutical Synthesis

The primary application of 4-oxo-1,4-dihydroquinoline-3-carboxylic acid lies in its role as a pharmaceutical intermediate. It is a critical precursor for synthesizing various drugs, most notably those targeting HIV, acting as a core structure for integrase inhibitors. Its chemical structure allows for further modifications to enhance drug efficacy, specificity, and pharmacokinetic profiles. Researchers also utilize it in the development of other therapeutic agents, tapping into the broad biological activity associated with the quinoline nucleus.

Sourcing Strategies for Your Business

When you need to purchase 4-oxo-1,4-dihydroquinoline-3-carboxylic acid, identifying a reliable supplier is key. Consider a manufacturer in China that can provide consistent quality, competitive pricing, and thorough documentation. As a leading CAS 13721-01-2 supplier, we emphasize stringent quality control and efficient production processes. We understand the importance of timely delivery and technical support for your critical projects. By partnering with us, you gain a strategic advantage in sourcing this vital chemical intermediate.

The chemistry of quinoline intermediates is a dynamic area, and 4-oxo-1,4-dihydroquinoline-3-carboxylic acid stands out for its utility. Its reliable synthesis and broad applicability ensure it remains a sought-after compound in the pharmaceutical industry.