The precise engineering of lipid-based delivery systems relies heavily on the chemical properties of their constituent lipids. Among these, functionalized phospholipids are gaining increasing importance for their ability to impart specific characteristics to formulations. This article explores the chemistry of 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(succinyl) (sodium salt), a vital lipid for advanced applications, and provides guidance for researchers looking to buy this material from a trusted supplier.

Decoding the Structure: 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-N-(succinyl) (Sodium Salt)

At its core, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(succinyl) (sodium salt) (CAS 111613-33-3) is a phospholipid built upon a glycerol backbone. Attached to this backbone are two long-chain fatty acid tails – specifically, oleic acid (18:1) in both the sn-1 and sn-2 positions. This diacyl structure provides the hydrophobic character essential for lipid assembly. The hydrophilic headgroup is a phosphoethanolamine moiety, which itself is modified by the addition of a succinyl group (-COCH2CH2COOH) to the amine nitrogen. The succinyl group introduces a carboxylate functionality, making the lipid zwitterionic at physiological pH and contributing a negative charge under certain conditions, depending on the pKa of the succinic acid moiety. The sodium salt form ensures improved solubility and handling characteristics. The purity, typically specified as ≥97.0%, is a testament to the meticulous synthesis and purification processes employed by manufacturers.

The Significance of Succinyl Modification in Formulations

The succinyl modification is not merely an aesthetic addition; it confers critical functional advantages. In the context of Lipid Nanoparticle (LNP) formulations, the succinyl group can:

  • Influence Particle Stability: The charge and steric properties of the headgroup can affect how the lipids self-assemble and pack, impacting the overall stability of the LNP structure.
  • Control Ionization and Charge: The carboxylic acid group allows for pH-dependent behavior, which can be leveraged for targeted release or improved cellular interactions.
  • Provide a Reactive Handle: The terminal carboxyl group can serve as a site for further chemical conjugation, allowing for the attachment of targeting ligands, imaging agents, or other functional molecules.

These chemical characteristics make succinyl PE a highly versatile building block for researchers aiming to optimize drug delivery systems, particularly for nucleic acid therapeutics where precise control over nanoparticle properties is paramount. For those looking to buy this lipid, understanding these chemical nuances is key to successful application.

From Synthesis to Supply: Ensuring Quality for Buyers

The journey of 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(succinyl) (sodium salt) from laboratory synthesis to a commercially available product involves rigorous chemical processes. Manufacturers employ multi-step synthetic routes, followed by advanced purification techniques such as chromatography, to achieve the high purity required. Quality control measures, including NMR spectroscopy, mass spectrometry, and HPLC, are essential to verify the structure and purity of each batch. For buyers, partnering with a supplier that demonstrates transparency in their manufacturing processes and provides detailed analytical data is crucial. When you decide to buy, consider suppliers who can offer lot-to-lot consistency and a scalable supply chain to meet your evolving needs.

Applications and the Future of Lipid Chemistry

The utility of succinyl PE extends beyond LNPs. Its chemical reactivity and amphipathic nature make it a candidate for developing novel biomaterials, diagnostic tools, and targeted drug conjugates. As the field of lipidomics and targeted therapeutics continues to expand, the demand for precisely engineered phospholipids with specific functional groups like succinyl PE will undoubtedly increase. Researchers and companies investing in these areas will benefit from a reliable supply of high-quality materials from expert manufacturers.

Conclusion

The chemistry of 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(succinyl) (sodium salt) offers significant advantages for advanced lipid formulations. Its unique succinyl modification provides a versatile platform for innovation in drug delivery and biomedical research. For procurement professionals and scientists seeking to buy this critical lipid, selecting a supplier committed to high purity, consistency, and technical expertise is essential for achieving successful outcomes. We are a premier manufacturer and supplier, ready to meet your advanced lipid needs. Contact us to learn more about our products and how we can support your research.