Tetraacetylribofuranose (CAS 13035-61-5) is a cornerstone intermediate in modern pharmaceutical synthesis, playing a vital role in the creation of essential medicines. As a protected form of ribose, its unique chemical structure and properties make it invaluable for researchers and manufacturers alike. This exploration covers its synthesis, key applications, and how professionals can secure reliable supply from leading manufacturers.

Synthesis and Chemical Properties

Tetraacetylribofuranose is typically synthesized through the acetylation of D-ribose. The process involves protecting the hydroxyl groups at the 1, 2, 3, and 5 positions with acetyl esters. This not only enhances its stability but also modifies its solubility, making it compatible with a broader range of organic solvents used in complex multi-step syntheses. Its molecular formula is C13H18O9, and it typically presents as a white to off-white crystalline powder with a purity often exceeding 98%. These characteristics are crucial for its predictable performance in synthesis.

Key Pharmaceutical Applications

The significance of Tetraacetylribofuranose in the pharmaceutical industry stems from its role as a precursor and building block:

  • Nucleoside and Nucleotide Synthesis: It is a critical starting material for synthesizing various nucleosides and nucleotides, which are fundamental components of DNA and RNA. This is essential for research into genetic disorders, cancer, and infectious diseases. Researchers often seek to buy this compound for its versatility in these synthetic routes.
  • Antiviral Drug Production: Notably, it serves as an intermediate in the synthesis of Ribavirin, a broad-spectrum antiviral drug used to treat hepatitis C, respiratory syncytial virus (RSV), and other viral infections. Ensuring a steady supply chain from a reliable supplier is vital for pharmaceutical companies manufacturing such medications.
  • Anticancer Therapies: In medicinal chemistry, Tetraacetylribofuranose is employed in the development of novel nucleoside analogs that can act as cytotoxic agents against cancer cells. Its structural features can be modified to create compounds that interfere with cancer cell replication.
  • Glycobiology Research: Scientists use this compound to study complex carbohydrate structures, glycosylation mechanisms, and the role of sugars in biological processes.

Sourcing and Purchasing Considerations

When procuring Tetraacetylribofuranose, professionals should focus on sourcing from reputable companies, particularly those operating as a manufacturer in China, known for its extensive chemical production capabilities. Key considerations include:

  • Quality Assurance: Verify the supplier's commitment to quality through certifications and comprehensive Certificates of Analysis (CoA).
  • Pricing: Obtain multiple quotes to ensure competitive pricing, especially for bulk purchases required for commercial production.
  • Technical Support: Partner with suppliers who offer technical assistance and detailed product documentation, aiding in process optimization and troubleshooting.

For those looking to purchase Tetraacetylribofuranose, engaging with established suppliers ensures access to a critical intermediate that drives pharmaceutical innovation. Reliability, purity, and cost-effectiveness are the hallmarks of a successful procurement strategy.