For researchers delving into the intricate world of ion channels, selecting the right tool is paramount. The TASK-1 (KCNK3) potassium channel, a member of the two-pore domain potassium channel family, plays a significant role in regulating cell membrane potential. Understanding its function is key to advancing research in areas like neuroscience and cardiovascular health. This is where potent and selective inhibitors like ML365 become indispensable.

ML365, identified by CAS number 947914-18-3, stands out as a highly effective pharmacological probe. Its defining characteristic is its potent and selective inhibition of TASK-1 channels, with reported IC50 values as low as 4 nM. This high degree of selectivity means that ML365 primarily targets TASK-1, exhibiting minimal inhibitory effects on other related potassium channels, such as TASK-3, and even less on more distantly related channels like Kir2.1, KCNQ2, and hERG. This specificity is crucial for obtaining clean and interpretable experimental results, allowing researchers to confidently attribute observed effects to the modulation of TASK-1.

For procurement managers and research scientists, the ability to reliably source high-purity ML365 is a critical consideration. As a dedicated manufacturer and supplier, we understand the importance of quality and consistency. Our ML365 is produced under stringent quality control measures, ensuring a purity of ≥98% by HPLC. This commitment to quality means that when you buy ML365, you are investing in a reagent that will perform predictably in your assays, whether for in vitro studies or for early-stage drug discovery programs.

The applications of ML365 are diverse, ranging from fundamental investigations into the physiological roles of TASK-1 channels to exploring potential therapeutic interventions. Its precise mechanism of action makes it a valuable asset for studies aiming to understand pain signaling, respiratory control, and cardiac electrophysiology. By providing this essential research chemical, we empower scientific exploration and innovation.

When considering your next purchase of ion channel modulators, think about the benefits of partnering with a reputable supplier. We offer ML365 at competitive prices, ensuring that your research budget is utilized effectively without compromising on quality. If you are looking to purchase ML365 or need a reliable manufacturer for your chemical synthesis needs, we are here to assist. Explore our offerings and discover how we can support your scientific breakthroughs.

For those seeking to purchase ML365 in China or globally, we provide efficient ordering and shipping services. Contact us today to get a quote or a free sample and learn more about how our high-quality ML365 can facilitate your research objectives.