When procuring pharmaceutical intermediates like Dibenz[b,e]oxepin-11(6H)-one (CAS 4504-87-4), buyers must navigate a complex interplay of price, quality, and supplier reliability. This pale yellow solid is a critical component in the synthesis of doxepin and other pharmaceutical compounds, making informed purchasing decisions essential.

Understanding Price Factors: The price of Dibenz[b,e]oxepin-11(6H)-one can vary significantly based on several factors:

  • Purity Level: Higher purity grades (e.g., 99%) command higher prices than lower grades, reflecting the increased complexity and cost of purification processes. For pharmaceutical applications, investing in high-purity material is non-negotiable.
  • Order Quantity: Bulk purchases of Dibenz[b,e]oxepin-11(6H)-one generally offer lower per-unit costs. Manufacturers in China often provide tiered pricing based on order volume, making it cost-effective for large-scale production.
  • Supplier Location and Logistics: The geographical origin of the supplier and the shipping method employed (air vs. sea freight) will influence the final landed cost. Sourcing from China can offer competitive pricing due to manufacturing efficiencies.
  • Supplier Reputation and Certifications: Established suppliers with ISO certifications and a proven track record in pharmaceutical intermediates may have slightly higher pricing but offer greater assurance of quality and reliability.

Assessing Quality: Quality is paramount for pharmaceutical intermediates. When evaluating suppliers, focus on:

  • Certificate of Analysis (COA): Always request a detailed COA for each batch. This document should confirm the purity (e.g., ≥99%), identity, and absence of critical impurities. Look for data from analytical techniques like GC, HPLC, NMR, and Mass Spectrometry.
  • Manufacturing Standards: Inquire about the supplier's manufacturing environment and adherence to GMP (Good Manufacturing Practices) principles, even if the intermediate itself is not an API.
  • Physical Appearance and Properties: Ensure the product matches the expected physical description (e.g., pale yellow solid) and that its properties (melting point, solubility) are consistent with specifications.
  • Supplier Audits and Transparency: For significant purchases, consider conducting a supplier audit or requesting detailed information about their quality management system. Transparency from the manufacturer regarding their processes is a good sign.

Where to Buy: When looking to buy Dibenz[b,e]oxepin-11(6H)-one, Chinese manufacturers are often the primary source due to their extensive production capabilities and competitive pricing structures. It is advisable to compare quotes from multiple suppliers, requesting both pricing and quality documentation upfront. This due diligence ensures you secure a dependable supply of high-quality Dibenz[b,e]oxepin-11(6H)-one at a price point that supports your manufacturing objectives.