(R)-(+)-1-Phenylethylamine (CAS 3886-69-9) stands out as a crucial compound for chemists and pharmacologists focused on enantiomeric purity. This chiral amine, often sourced from reputable manufacturers, plays a pivotal role in analytical chemistry and synthetic processes aimed at producing single-enantiomer drugs. Understanding its function is key for R&D scientists and procurement specialists looking to buy high-quality chiral intermediates.

The Significance of Enantiomeric Purity

Many biologically active molecules, particularly pharmaceuticals, exist as enantiomers. These enantiomers can have vastly different effects on the human body; one might be therapeutic, while the other could be inactive or even toxic. Therefore, the ability to accurately determine and achieve high enantiomeric purity is critical in drug development and manufacturing. (R)-(+)-1-Phenylethylamine is instrumental in this endeavor.

(R)-(+)-1-Phenylethylamine as a Purity Determinator

The compound's utility in determining the purity of acid enantiomers stems from its ability to form diastereomeric salts. When reacted with a mixture of enantiomers of a chiral acid, (R)-(+)-1-Phenylethylamine reacts with each enantiomer to form two different diastereomeric salts. Diastereomers have different physical properties, such as solubility and melting points, which allows for their separation through techniques like fractional crystallization. By analyzing the composition of these separated salts or the residual material, one can ascertain the enantiomeric excess (ee) of the original chiral acid. This method provides a reliable way to quantify chiral purity.

Applications in Chiral Resolution and Synthesis

Beyond its analytical applications, (R)-(+)-1-Phenylethylamine is widely used as a chiral resolving agent in preparative chemistry. It facilitates the separation of enantiomers on a larger scale, making it possible to obtain pure enantiomers of chiral acids for further synthesis. Moreover, as a chiral building block, it is incorporated into the synthesis of complex molecules, imparting specific stereochemistry. When you need to buy this compound, looking for suppliers that emphasize its purity (typically >99%) and optical activity ([α]20/D +38°, neat is a common specification) is important.

Sourcing (R)-(+)-1-Phenylethylamine: What to Look For

Procuring (R)-(+)-1-Phenylethylamine requires attention to detail. As a buyer, you should seek out manufacturers and suppliers who can guarantee high assay values, provide detailed technical data sheets (TDS), and offer competitive pricing for bulk purchases. Companies like NINGBO INNO PHARMCHEM CO.,LTD. are known for their commitment to quality, offering this essential chiral amine with robust support for pharmaceutical R&D and manufacturing. Ensuring a stable supply chain from a reliable partner is paramount for consistent project execution.

For your next project requiring precise chiral analysis or synthesis, consider sourcing your (R)-(+)-1-Phenylethylamine from a trusted Chinese manufacturer. Reach out to us today to inquire about pricing and availability.