In the demanding landscape of pharmaceutical manufacturing, the quality and consistent availability of raw materials are non-negotiable. For companies engaged in the synthesis of advanced antibacterial agents, 4-Nitrobenzyl Hydrogen Malonate (CAS 77359-11-6) is a compound of significant interest. This article delves into its essential properties and provides insights into sourcing this vital intermediate effectively.

Understanding the Chemical Profile of 4-Nitrobenzyl Hydrogen Malonate

4-Nitrobenzyl Hydrogen Malonate is an organic compound characterized by its molecular formula C10H9NO6 and a molecular weight of 239.18. It typically presents as a white to almost white powder, with a confirmed melting point of 109°C. Its solubility in methanol further contributes to its versatility in various chemical synthesis processes. These properties make it a well-defined and manageable intermediate for complex organic transformations.

Applications in Pharmaceutical Synthesis

The primary utility of 4-Nitrobenzyl Hydrogen Malonate lies in its role as a key intermediate for the synthesis of beta-lactam antibiotics, particularly in the development of thienamycin and other carbapenem-based drugs. These antibiotics are crucial for treating serious infections, especially those caused by resistant bacteria. As a chiral building block, it is instrumental in constructing the stereochemically precise structures required for optimal therapeutic efficacy. For R&D scientists and production managers, securing a consistent supply of this intermediate is fundamental to their operations.

Strategic Sourcing for Pharmaceutical Intermediates

When the need arises to buy 4-Nitrobenzyl Hydrogen Malonate, it is imperative to partner with reliable suppliers and manufacturers. Companies specializing in fine chemicals, particularly those with a strong presence in regions like China, often offer high-purity grades (e.g., 99%+ assay) crucial for pharmaceutical applications. These suppliers can provide detailed technical specifications, safety data sheets (MSDS), and certificates of analysis (CoA) to ensure product quality. Establishing a relationship with a trusted manufacturer not only guarantees product integrity but also ensures competitive pricing and a stable supply chain, preventing potential disruptions in your production schedule.

For any pharmaceutical company focused on antibiotic development or manufacturing, ensuring a dependable source for intermediates like 4-Nitrobenzyl Hydrogen Malonate is a strategic imperative. Exploring options from established suppliers is key to maintaining operational efficiency and product quality.