The pharmaceutical industry's ability to deliver life-saving treatments hinges on the reliable supply of high-quality chemical intermediates. For the production of advanced anti-cancer drugs like paclitaxel and docetaxel, 10-Deacetylbaccatin III (CAS 32981-86-5) is an indispensable precursor. This article offers expert guidance on sourcing this critical compound, particularly from established Chinese manufacturers.

The Role of 10-Deacetylbaccatin III in Drug Synthesis

10-Deacetylbaccatin III is a complex natural product derived from the Taxus species. Its chemical structure (C29H36O10, MW 544.59) provides the foundational diterpenoid skeleton necessary for creating the highly effective taxane class of chemotherapeutic agents. These drugs operate by stabilizing microtubules, thereby preventing cancer cell division. The critical pathway involves using 10-Deacetylbaccatin III as the starting material for semi-synthesis, allowing for the strategic addition of side chains that impart therapeutic activity. As such, securing a consistent supply of 10-Deacetylbaccatin III is a cornerstone of pharmaceutical manufacturing for these oncology drugs.

Key Considerations for Procurement Managers

When seeking to buy 10-Deacetylbaccatin III, procurement managers must prioritize several factors to ensure the integrity of their manufacturing processes:

  • Purity and Assay Specifications: The product must meet strict purity standards, typically confirmed by HPLC analysis (e.g., ≥98.00% or ≥99.00%). Consistency in purity is vital for predictable reaction yields and minimal downstream purification challenges.
  • Appearance: A white to off-white crystalline powder is the standard physical form. Deviations may indicate issues with processing or purity.
  • CAS Number Verification: Confirming the CAS number (32981-86-5) ensures the correct chemical entity is being sourced.
  • Supplier Reliability: Choosing a manufacturer with a proven track record in producing high-quality pharmaceutical intermediates is paramount. This includes strong quality assurance systems and responsive customer support.

Why Source from China?

China has emerged as a global hub for chemical manufacturing, offering a combination of advanced technological capabilities, competitive pricing, and vast production capacity. For companies looking to order 10-Deacetylbaccatin III, partnering with a reputable Chinese 10-Deacetylbaccatin III supplier can offer significant advantages. These advantages include access to efficient production lines, rigorous quality control protocols, and a stable supply chain, which are all crucial for pharmaceutical manufacturing operations. We pride ourselves on being a leading Chinese supplier committed to delivering exceptional quality and value.

By carefully evaluating suppliers and focusing on the critical specifications, pharmaceutical manufacturers can secure the essential 10-Deacetylbaccatin III needed to produce advanced cancer therapies, contributing to better patient outcomes worldwide.