In the relentless pursuit of effective cancer treatments, certain chemical compounds stand out as foundational pillars. Among these is 10-Deacetylbaccatin III (CAS 32981-86-5), a naturally derived diterpenoid that plays an indispensable role as a precursor in the synthesis of some of the most impactful chemotherapeutic agents known: paclitaxel and docetaxel. For pharmaceutical researchers and procurement managers, understanding the significance and sourcing of this compound is paramount.

What is 10-Deacetylbaccatin III?

10-Deacetylbaccatin III is a complex organic molecule primarily isolated from the needles and bark of yew trees, particularly those belonging to the Taxus genus. Its chemical structure, characterized by a highly oxygenated diterpenoid framework, makes it an ideal starting material for constructing the intricate architecture of taxane-based drugs. Typically appearing as a white or off-white crystalline powder, its purity is a critical factor in its efficacy as an intermediate.

The Critical Link to Cancer Therapies

The paramount importance of 10-Deacetylbaccatin III lies in its direct utility in the semi-synthesis of paclitaxel (Taxol) and docetaxel (Taxotere). These drugs are widely recognized for their ability to interfere with cell division by stabilizing microtubules, thereby halting the proliferation of cancer cells. The low natural abundance of paclitaxel itself led to the development of efficient synthetic routes, with 10-Deacetylbaccatin III being the key intermediate that allows for the subsequent addition of essential side chains to create these potent anti-cancer drugs. Therefore, a reliable supplier of 10-Deacetylbaccatin III is crucial for the continuous production of these essential medicines.

Why Choose a Chinese Manufacturer for Your Supply?

When sourcing critical pharmaceutical intermediates like 10-Deacetylbaccatin III, choosing the right manufacturer is key. Many leading global suppliers and R&D institutions rely on expert chemical manufacturers in China. These manufacturers often offer:

  • Competitive pricing: Secure cost-effective solutions without compromising on quality.
  • Advanced manufacturing capabilities: Access to state-of-the-art facilities and synthesis techniques.
  • Stringent quality control: Assurance of high purity (often >98% or >99% by HPLC) and adherence to international standards.
  • Scalability: Ability to meet both small research batch needs and larger bulk purchase orders.

For procurement managers seeking to buy 10-Deacetylbaccatin III, partnering with a reputable 10-Deacetylbaccatin III manufacturer in China can provide a significant strategic advantage. It ensures a stable supply chain, access to high-quality material, and supports the continuous development and availability of life-saving cancer treatments.

Key Specifications to Look For

When evaluating potential suppliers, pay close attention to key specifications:

  • Appearance: White or almost white crystalline powder.
  • Purity (HPLC): Typically ≥98.00% or ≥99.00%.
  • CAS Number: 32981-86-5.
  • Molecular Formula: C29H36O10.
  • Molecular Weight: 544.59 g/mol.

By focusing on these details and partnering with a trusted chemical supplier, your organization can confidently procure 10-Deacetylbaccatin III, paving the way for advancements in cancer therapy. We are committed to being your reliable partner in sourcing this critical pharmaceutical intermediate.